High Migratory Activity of Dermal Sheath Cup Cells and Clinical Efficacy in Autologous Therapy for Hair Loss

November 2023 in “ Journal of Dermatological Science ”

Yumiko Ishimatsu‐Tsuji, Shiro Niiyama, Ryokichi Irisawa, Kazutoshi Harada, Jiro Kishimoto, Ryoji Tsuboi

dermal sheath cup cells autologous cell-based therapy pattern hair loss cell migration integrin subunit alpha 6 ITGA6 hair follicles DSC cells cell-based therapy hair loss cell movement hair roots

Studysummary This study found that ITGA6-positive dermal sheath cup cells, identified by their superior migratory activity, may enhance cell-based therapy for male and female pattern hair loss by promoting cell migration into hair follicles. Our plain-language summary of this paper — not a Tressless recommendation.

The study "High migratory activity of dermal sheath cup cells associated with the clinical efficacy of autologous cell-based therapy for pattern hair loss" investigates the mechanisms underlying the efficacy of dermal sheath cup (DSC) cells in cell-based therapy for pattern hair loss. The researchers conducted multivariate analysis to categorize individuals based on treatment response as responders and non-responders. They identified nine and three genes as high efficacy (HE) and low efficacy (LE) marker genes, respectively. The HE subpopulations were enriched for cell migration-related genes, while the LE subpopulation was enriched for basement membrane and vasculature-related genes. The study found that DSC cells expressing integrin subunit alpha 6 (ITGA6), an HE subpopulation gene, had markedly higher mobility than those expressing the LE subpopulation genes. The conclusion is that ITGA6-positive DSC cells, with superior migratory activity, may contribute to cell-based therapy by promoting cell migration into nearby hair follicles.

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