TLDR Different parts of the body's fat tissue have unique cell types and characteristics, which could help treat chronic wounds.
The study used single-cell RNA sequencing to analyze adipose tissue samples from different anatomical sites, identifying specific cellular differences and dynamics between groups of cells. Ten separate cell types were identified, each with unique characteristics and involvement in metabolism-related pathways. The study also revealed alterations at the cellular and molecular level, including in biological signaling pathways. Some subpopulations of human adipose stem cells showed higher cell stemness, potentially beneficial for treating chronic refractory wounds. The data can be a valuable resource for constructing a human single-cell transcriptome atlas across adipose depots, aiding in understanding the function and role of cells with specific alterations in adipose tissue. However, the authors suggest that a larger number and diversity of adipose tissue samples should be collected for future studies.
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November 2018 in “Physiological Reviews” The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.
