Effect of Mycophenolic Acid on Proliferation of Dermal Papilla Cells and Induction of Anagen Hair Follicles

March 2015 in “ Clinical and experimental dermatology ”

Kwan Jeong, Hong Jin Joo, J. E. Kim, Y. M. Park, Hoon Kang

mycophenolic acid dermal papilla cells anagen hair follicles Axin2 Wnt/ERK pathway Bcl-2/Bax ratio minoxidil microneedle treatment MPA DPCs MXD MN

TLDR Mycophenolic acid may help treat hair loss by promoting hair growth and cell proliferation.

The study investigated the effects of mycophenolic acid (MPA) on dermal papilla cells (DPCs) and hair growth in mice. MPA promoted DPC proliferation, increased Axin2 transcription, and activated the Wnt/ERK pathway. It also enhanced the Bcl-2/Bax ratio, contributing to cellular proliferation. Topically applied MPA induced anagen hair follicles in mice, showing effects similar to minoxidil (MXD), which were further enhanced by microneedle (MN) treatment. The findings suggested that MPA could be a potential treatment for hair-loss disorders.

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Effect of Mycophenolic Acid on Proliferation of Dermal Papilla Cells and Induction of Anagen Hair Follicles

Research cited in this study

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