Hair Follicle Reformation Induced by Dermal Papilla Cells from Human Scalp Skin

The study investigated the potential of dermal papilla cells from human scalp skin to induce hair follicle reformation both in vivo and in vitro. Researchers used dermal papilla and dermal sheath cells, combined with collagen gels, to create mesenchymal cell-populated structures. These were then cultured with various epithelial cells to form bilayer artificial skins. When transplanted into nude mice, these recombinants successfully reformed hair follicle-like structures, demonstrating that dermal papilla cells could induce hair follicle formation through interaction with epithelial cells. The study concluded that low passage dermal papilla cells, when mixed with hair follicle epithelial cells, could reform typical hair follicle structures and produce hair fibers, highlighting the regenerative potential of these cells in hair follicle formation.