TLDR Recent progress has been made in understanding inherited hair and nail disorders.
The document discussed the development and genetic disorders of hair and nails. Hair follicles begin forming in the 10th week of gestation, influenced by mesodermal and ectodermal interactions, while nail development starts around the 9th week and completes by the fifth month. Various genetic disorders affect hair and nails, including disorders of hair morphogenesis, cycling, and shaft structure, as well as isolated congenital nail dysplasia and pachyonychia congenita types 1 and 2. Advances in understanding the molecular basis of these disorders have improved diagnosis and provided options for premarital counseling and prenatal diagnosis, significantly impacting affected families.
52 citations,
November 2003 in “Journal of Investigative Dermatology” Different harmful mutations in the CDH3 gene cause HJMD, but symptoms vary among individuals.
26 citations,
October 2002 in “Journal of Investigative Dermatology” A specific gene mutation causes congenital hair loss.
15 citations,
April 2002 in “British Journal of Dermatology” Hairless gene not strongly linked to baldness.
139 citations,
September 2001 in “The journal of investigative dermatology/Journal of investigative dermatology” Mutations in the Vitamin D receptor gene can cause hair loss similar to mutations in the Hairless gene.
236 citations,
July 2001 in “Trends in Molecular Medicine” Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.
2 citations,
June 2000 in “Journal of The American Academy of Dermatology” Mutation in hairless gene may increase hair loss risk.
20 citations,
April 2000 in “Experimental dermatology” ODC transgenic mice can model human hair loss with skin lesions.
16 citations,
August 1992 in “Archives of dermatological research” Lab-grown nail cells show characteristics similar to natural nail and hair.
