Cultured Nail Keratinocytes Express Hard Keratins Characteristic of Nail and Hair In Vivo

    August 1992 in “ Archives of dermatological research ”
    Takashi Kitahara, Hideoki Ogawa
    Image of study
    TLDR Lab-grown nail cells show characteristics similar to natural nail and hair.
    In the 1992 study by Kitahara and Ogawa, researchers cultured cells from the human ventral nail matrix and confirmed the expression of hard keratins, which are found in both nail and hair but not in the epidermis, using indirect immunofluorescence. The presence of hard keratins in these cells suggested that they could serve as a marker for cultured nail cells and that these cells express differentiation-related keratins at a calcium concentration of 0.15 mM, which may indicate they are in the differentiation stage. This research provided a model for studying the differentiation of nail and potentially hair cells in vitro, although the study did not specify the number of participants as it used cells from a single healthy adult man.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 1000+ results

      community Why does my hair look so much less bald after shower vs upon waking up?

      in Chat  7 upvotes 1 year ago
      The conversation discusses the user's observation of their hair appearing less bald after showering compared to when they wake up. They use a biotin and keratin conditioner and ketoconazole twice a week, while others suggest the difference in appearance could be due to oil build-up or the hair's response to water.

      community Results of Procyanidin B2 in clinical studies

      in Treatment  13 upvotes 4 years ago
      Procyanidin B2, a compound derived from Annurca apples, as a potential treatment for pattern hair loss. Several clinical studies were mentioned, which found that procyanidin B2 could increase hair growth, density, and keratin content. Other treatments such as Minoxidil, Finasteride, and RU58841 were not discussed.

      community Taurine supplements work for hair growth?

      in Product  8 upvotes 6 months ago
      The conversation discusses taurine supplements for hair growth, highlighting their potential to reduce DHT and improve hair health. A user comments that people often try alternatives to finasteride.

      community 1 year and 2 months on fin and no regrowth

      in Chat  13 upvotes 11 months ago
      The user has seen no regrowth after 1 year and 2 months on finasteride, despite increasing the dose, and is inquiring about the potential of future treatments like verteporfin and gt20029 for hair regrowth.

      community 15-Month Update - Dut, Min, Niz, 1.5mm Roller.

      in Progress Pictures  314 upvotes 9 months ago
      The user shared a 15-month hair loss treatment update using Dutasteride (0.5mg/day), Minoxidil (5% foam twice daily), Nizoral (1% every 3 days), and a 1.5mm derma roller (twice a month), along with a multivitamin, exercise, low sugar diet, hydration, and consistent sleep. They started seeing results after 6-9 months, with significant improvement at the 1-year mark, and apply Minoxidil the day after derma rolling.

      community Why aren’t hair fibers popular?

      in Product  22 upvotes 1 year ago
      Hair fibers are discussed as a temporary solution for hair loss, with users noting they work well if applied correctly but can be messy and time-consuming. Some users also use finasteride for long-term treatment.

    Similar Research

    5 / 1000+ results