Fibroblast Lineage Switching as the Developmental Origin of Scarring and Target for Regenerative Healing
January 2026
in “
Preprints.org
”
fibroblast lineage switching scarring regenerative healing fetal wound healing adult wound healing pro-regenerative fibroblasts pro-fibrotic fibroblasts extracellular matrix ECM collagen type III collagen type V anti-inflammatory cytokines integrin–focal adhesion kinase pathway FAK pathway fibroblast heterogeneity papillary fibroblasts reticular fibroblasts scarless tissue repair scarless healing wound healing collagen anti-inflammatory
Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.
Studysummary This review explores current knowledge on fibroblast lineage specification and its impact on scar-free wound healing, noting that early fetal skin fibroblasts support regeneration, while later developmental shifts lead to fibrosis, highlighting potential strategies to reprogram adult fibroblasts for regenerative repair.
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