Distinct Fibroblast Lineages Give Rise to NG2+ Pericyte Populations in Mouse Skin Development and Repair

    May 2021 in “ Frontiers in Cell and Developmental Biology ”
    Georgina Goss, Emanuel Rognoni, Vasiliki Salameti, Fiona M. Watt
    Studysummary This study found that Ng2+ perivascular cells in mouse skin are a diverse lineage-restricted population primarily recruited from papillary or reticular fibroblast lineages during wound healing, maintaining heterogeneity in both wounded and non-wounded skin. Our plain-language summary of this paper — not a Tressless recommendation.
    The study demonstrated that NG2+ pericytes in mouse skin originated from distinct fibroblast lineages, specifically Lrig1+ papillary and Dlk1+ reticular fibroblasts, during both skin development and wound repair. These pericytes were lineage-restricted to blood vessel-associated populations and did not contribute to other dermal cell types. The research highlighted the heterogeneity within the perivascular niche, identifying four distinct NG2+ perivascular cell populations based on Pdgfrα and Pdgfrβ expression. NG2 was consistently expressed by 70-80% of perivascular cells, making it a reliable marker for identifying pericytes. The study provided insights into the lineage origins and roles of pericytes, emphasizing their crucial role in vascular regeneration during skin repair.
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