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research Multi-Scale Spatial Mapping of Cell Populations Across Anatomical Sites in Healthy Human Skin and Basal Cell Carcinoma

1 citations , August 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

The research created a detailed map of skin cells, showing that certain cells in basal cell carcinoma may come from hair follicles and could help the cancer grow.

research Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts During Wound Healing

128 citations , August 2020 in “Cell stem cell”

Dermal fibroblasts have adjustable roles in wound healing, with specific cells promoting regeneration or scar formation.

research Defining the Transcriptional Signature of Esophageal-to-Skin Lineage Conversion

3 citations , February 2021 in “bioRxiv (Cold Spring Harbor Laboratory)”

Adult esophageal cells can start to become like skin cells, with a key pathway influencing this change.

research Repurposing of Drugs as Novel Influenza Inhibitors From Clinical Gene Expression Infection Signatures

42 citations , January 2019 in “Frontiers in Immunology”

A blood pressure drug, diltiazem, may also help treat influenza.

Comparative Spatial Transcriptomic and Single-Cell Analyses of Human Nail Units and Hair Follicles Show Transcriptional Similarities between the Onychodermis and Follicular Dermal Papilla

research Comparative Spatial Transcriptomic and Single-Cell Analyses of Human Nail Units and Hair Follicles Show Transcriptional Similarities between the Onychodermis and Follicular Dermal Papilla

10 citations , July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Human nails and hair follicles have similar gene activity, especially in the cells that contribute to their growth and development.

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community 57% increased chance of pattern hair loss independently associated with the consumption of sugary beverages in men (p<0.001) Pt 2

in Research/Science 479 upvotes 1 year ago

Sugary beverages increase the risk of pattern hair loss in men by 57%. Treatments discussed include Minoxidil, finasteride, and RU58841.

community Minoxidil is a 5ar inhibitor according to research

in Research/Science 146 upvotes 1 week ago

Minoxidil may inhibit androgen receptors and affect hormonal pathways, potentially explaining its effectiveness in treating androgenetic alopecia (AGA). Users discuss its varying effectiveness on scalp versus facial hair and note fewer side effects with topical use compared to oral.

community Testosterone in Reference Range Doesn't Cause Hair Loss

in Research/Science 51 upvotes 1 year ago

Testosterone within the normal range does not significantly contribute to male pattern baldness (MPB); DHT is the main factor that can be controlled. Genetics play a crucial role in hair loss, and treatments like finasteride and dutasteride, which block DHT, can help despite potentially raising testosterone levels.

community JXL082 is not PP405 and Everychem followed the wrong lead

in Research/Science 35 upvotes 2 months ago

JXL082 is not the same as PP405, leading to a halt in sales and a plan to synthesize the real PP405. There is skepticism about the safety and effectiveness of JXL082 and PP405, with concerns about patent issues and the long-term impact on hair growth.

community Minoxidil Response Bottlenecks: Why Sulfation and Transport Matter (And Where Tretinoin Fits In)

in Research 461 upvotes 4 months ago

Minoxidil's effectiveness is limited by the need for sulfation and proper transport to hair follicles, with tretinoin potentially enhancing its effects by promoting enzyme activity and keratinocyte differentiation. Tretinoin may improve minoxidil's response by boosting the expression of necessary enzymes and transporters.

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