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    Glossary Signal Transducer and Activator of Transcription 5

    protein that transmits signals to influence gene expression

    Signal Transducer and Activator of Transcription 5 (STAT5) is a protein that plays a crucial role in transmitting signals from the cell surface to the nucleus, where it can influence gene expression. It is particularly important in processes like cell growth, differentiation, and immune function. In the context of hair biology, STAT5 can be involved in the regulation of hair follicle development and cycling.

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    1. Signal transducer and activator of transcription 5B deficiency due to a novel missense mutation in the coiled-coil domain 2018 · 14 citations
    2. Expression of Signal Transducer and Activator of Transcription-3 in Androgenetic Alopecia: A case control study Skin Pharmacology and Physiology · 2022
    3. IN-SILICO STUDY OF BIOACTIVE COMPOUNDS OF NATURAL MATERIALS AS A JAK- SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION INHIBITOR FOR ANTI-ALOPECIA Asian journal of pharmaceutical and clinical research · 2017
    4. 59 Scarring alopecia is driven by the collapse of EGFR-protected JAK-STAT1-sensitive stem cell immune privilege 2023
    5. The JAK/STAT signaling pathway: from bench to clinic Signal Transduction and Targeted Therapy · 2021 · 489 citations
    6. Leptin and the skin: a new frontier Experimental Dermatology · 2009 · 108 citations
    7. Two distinct signaling pathways in hair cycle induction: Stat3-dependent and -independent pathways Proceedings of the National Academy of Sciences of the United States of America · 2000 · 73 citations
    8. JAK-STAT1 as therapeutic target for EGFR deficiency-associated inflammation and scarring alopecia EMBO Molecular Medicine · 2024 · 8 citations
    9. Janus kinase inhibitors for alopecia areata: a review of clinical data Frontiers in Immunology · 2025 · 4 citations
    10. 0975 Single-cell transcriptomic profiling reveals distinct immunopathogenic programs in alopecia totalis/universalis compared to patchy alopecia areata Journal of Investigative Dermatology · 2026
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