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GlossarySignal Transducer and Activator of Transcription 5

protein that transmits signals to influence gene expression

Signal Transducer and Activator of Transcription 5 (STAT5) is a protein that plays a crucial role in transmitting signals from the cell surface to the nucleus, where it can influence gene expression. It is particularly important in processes like cell growth, differentiation, and immune function. In the context of hair biology, STAT5 can be involved in the regulation of hair follicle development and cycling.

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community Physician here AMA – 30M oral Fin 1-1.25 mg daily

in Update 47 upvotes 2 years ago

Hair loss treatments, specifically the use of finasteride, microneedling and potentially oral minoxidil. People discussed their experiences with finasteride, its effects on sexual behaviors, as well as potential solutions such as tadalafil or using other growth factor signal peptides for hope in curing male pattern baldness.

community medication for hair loss spironolactone

in Female 3 upvotes 1 year ago

41-year-old female experienced slow hair thinning, took finasteride for a year, then switched to spironolactone. Irregular periods occurred, seeking advice on long-term side effects and considering a third medication.

community Acute shedding episodes. Had telogen effluvium last year. Remission for a few months(thought I was over the shedding stuff 🥲). Now if I have any major stress days, THAT day I get a major shed and a few days after.

in Female 3 upvotes 2 months ago

The user experiences immediate hair shedding linked to stress, unlike typical telogen effluvium, and is seeking answers. A suggestion was made to use spironolactone and topical minoxidil to address potential DHT-related shedding.

community Calecim (PTT-6) Advanced Hair System with Topical Exosomes and Growth Factors for Hair Growth

in Treatment 2 months ago

Calecim (PTT-6) Advanced Hair System is a 6-week hair restoration product using stem cell-derived ingredients to stimulate hair growth. Users are skeptical, calling it overpriced and ineffective, suggesting alternatives like LLLT devices or PRP treatments.

community Minoxidil and Caffeine - opposite effects yet comboed together?

in Product 1 upvotes 3 months ago

Minoxidil and caffeine are discussed for hair loss treatment. The user questions the logic of combining them due to their opposing effects on adenosine receptors.

community 25-31 recovery makes my hair almost unmanageable.

in Progress Pictures 17 upvotes 7 months ago

A user shared their hair recovery progress from ages 25-31, attributing success to quitting smoking, minoxidil, microneedling, and hormone therapy. They also mentioned being transgender and using hormone therapy.

community Aronia Chokeberry and Cyanidin 3-O-arabinoside for Hair Growth (AGA) Study

in Research/Science 14 upvotes 10 months ago

A natural compound called C3A from Aronia Chokeberry can help prevent hair loss by counteracting the effects of DHT. The user has been taking 50 grams of dried organic Aronia Chokeberry daily for 30 days and will update with photos in 60 days.

community hmi115 is coming. Prepare yourselves for what's coming

in Technology 104 upvotes 1 year ago

The conversation discusses HMI-115, a potential cure for hair loss. Users share mixed opinions, with some expressing skepticism and others sharing anecdotal evidence of its effectiveness, including photos of significant hair regrowth from a trial participant.

community Why is dht bad for scalp hair but good for hair on the rest of body?

in Satire 109 upvotes 1 year ago

The conversation discusses why DHT (dihydrotestosterone) negatively affects scalp hair but promotes growth elsewhere on the body. Various opinions include genetic predispositions, differences in hair follicle reactions to DHT, and the potential role of Omega-3 in reducing inflammation and promoting hair health.

community Month 5 – Fin, min, microneedling 1x month.

in Progress Pictures 70 upvotes 1 year ago

User made progress with hair loss using Fin, Min, and microneedling. Experienced side effects like improved skin, brain fog, and memory issues, but adjusting Fin dosage helped.

community New drug for hair loss announced by Amplifica

in Research/Science 161 upvotes 1 year ago

Amplifica starting clinical trials for new hair loss drug. SCUBE3 protein discovered, stimulates hair growth, could be alternative to Minoxidil and Finasteride.

community PP405: The Ultimate Hair Loss Drug for Complete Hair Growth

in Research/Science 198 upvotes 2 days ago

PP405 is a new hair loss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hair follicle stem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.

community 2~ year progress update! 1mg FIN 2.5mg oral MIN daily. (26)

in Progress Pictures 1547 upvotes 4 months ago

User shared a 2-year progress update on hair regrowth using 1mg finasteride and 2.5mg oral minoxidil daily. They switched from topical to oral minoxidil for ease of use and showed significant improvement.

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

in Research/Science 74 upvotes 5 months ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community Caffiene shampoos left in for 2 minutes show comparable results to Minoxidil, and may work differently than Minoxidil, which can add to your stack, or work for non responders

in Research/Science 42 upvotes 6 months ago

Caffeine shampoos show comparable results to Minoxidil and may enhance its effects when used together. Caffeine can be detected in the scalp up to 24 hours after a 2-minute application, making it an affordable treatment option.

community New Research- Creatine Increasing Scalp DHT Without Corresponding Serum DHT Increase

in Research/Science 120 upvotes 7 months ago

Creatine may increase scalp DHT without affecting serum DHT, potentially speeding up male pattern baldness (MPB) for those genetically prone. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community M20 1.5 months vs 8 months fin + min

in Is this regrowth? 6 upvotes 7 months ago

A 20-year-old male has been using 1mg finasteride and 5% minoxidil daily for 1.5 to 8 months and is unsure about regrowth. Suggestions include continuing the treatment, trying microneedling, or considering oral minoxidil.

community Androgenic alopecia exclusively on the vertex of the scalp

in Chat 6 upvotes 7 months ago

A user experienced androgenic alopecia starting at the vertex without frontal hairline recession and is seeking information on this pattern. Another user noted that vertex or diffuse hair loss is common among men.

community Not sure if fin is enough, still losing lots of hair

in Finasteride/Dutasteride 6 upvotes 8 months ago

The user has been on finasteride for 17 months to treat hair loss, with some improvement in the crown but still experiencing significant shedding. They are considering if finasteride alone is sufficient and are hesitant to use minoxidil due to a pre-existing condition, while another person suggests trying dutasteride.

community Expectations control for SCUBE3

in Research/Science 21 upvotes 9 months ago

SCUBE3, a protein linked to hair growth in moles, was discovered over 25 years ago and is being developed by Amplifica for potential hair loss treatment. Concerns exist about SCUBE3's association with cancer, as it is a protein that promotes cell growth, which could potentially trigger cancer development if used for hair growth therapy.

community Can a folate deficiency make androgenetic alopecia worse?

in Treatment 1 upvotes 11 months ago

The user is treating androgenetic alopecia with finasteride and discovered a folic acid deficiency. They are asking if curing the deficiency can worsen or improve their hair condition.

community Has anyone tried PRP and Exosomes?

in Chat 2 upvotes 1 year ago

The user asked for opinions on a hair loss treatment involving PRP and Exosomes. They recently tried this treatment.

community RU users hands up I wanna hear your miracolous and horror stories.

in Treatment 44 upvotes 1 year ago

The experiences of users who have used RU58841 to treat hair loss, including both positive and negative effects. Some side effects reported include chest pain, joint pain in the hands, tinnitus, and increased heartbeat.

community Are there a lot of young folks here on fin?

in Chat 1 year ago

Young people who have used finasteride and minoxidil to treat hair loss, with generally positive results reported by those taking the treatments.

community Starting Year 2 of Low-Dose Oral Minoxidil – How Do I Look?

in Satire 2 years ago

This conversation is about a user's experience with low-dose oral Minoxidil for hair loss, and includes advice from other users who suggest trying finasteride or microneedling, as well as shaving off the remaining hair and seeking a hair transplant in Turkey. It was originally intended as satire but had to be clarified due to confusion.

community Comprehensive Microneedling Guide

in Microneedling 290 upvotes 2 years ago

Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

community [19M] Before and after pics 8 months after consistent use of Finasteride 1 mg and Minoxidil 5% 1ml every night, ketokonazole2%+salicylic acid mild shampoo everyday. I've used minoxidil only for the frontal, most significant area of the scalp for regrowth as 1 ml is not enough for entire scalp

in Progress Pictures 224 upvotes 3 years ago

User shared before and after photos of 8 months using Finasteride 1mg and Minoxidil 5% 1ml nightly, with positive results and no side effects. Others praised the progress and suggested alternative treatments like topical fin, CB-03-01, or RU58841.

community 1 year fin 1mg and minox. can see some density reclaimed

in Update 562 upvotes 3 years ago

User shared 1-year progress using finasteride 1mg and minoxidil, regaining hair density. Others praised the improvement and asked about side effects and additional treatments.

community Anyone use Verteporfin with their hair transplant yet?

in Transplants 12 upvotes 3 years ago

User discusses using Verteporfin for hair regrowth after hair transplant. Replies mention successful follicle regrowth in studies and mice, questioning if it can be replicated in humans.

community Two month progress – Min/Dermarolling/Hair Savior Oil. Don’t mind the min-druff

in Progress Pictures 208 upvotes 3 years ago

User reports two-month progress using Min, dermarolling, and Hair Savior Oil. Others suggest adding Ketoconazole for dandruff and hair growth, and continuing Min use to maintain results.