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    Glossary Transcription Co-activator

    protein that helps activate gene expression by binding to transcription factors

    A transcription co-activator is a protein that helps turn on the expression of specific genes by binding to transcription factors, which are proteins that directly interact with DNA. While co-activators do not bind to DNA themselves, they facilitate the assembly of the transcription machinery, enhancing the efficiency of gene transcription. This process is crucial for regulating various biological functions, including hair growth and the response to conditions like alopecia.

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    1. The Transcriptional Co-Activator cAMP Response Element-Binding Protein-Binding Protein Is Expressed in Prostate Cancer and Enhances Androgen- and Anti-Androgen-Induced Androgen Receptor Function American Journal of Pathology · 2003 · 72 citations
    2. Lack of androgen receptor transcriptional activity in human keratinocytes Journal of dermatological science · 2000 · 30 citations
    3. Distinct use of super-enhancer elements controls cell type–specific CD25 transcription and function Science Immunology · 2023 · 10 citations
    4. Many Paths to Alopecia via Compromised Regeneration of Hair Follicle Stem Cells Journal of Investigative Dermatology · 2013 · 8 citations
    5. Langerin+ Dendritic Cells in Cutaneous Fibrosis: The TGF-β1 Signaling Axis Clinical Cosmetic and Investigational Dermatology · 2025
    6. Leptin and the skin: a new frontier Experimental Dermatology · 2009 · 108 citations
    7. Transcriptional activation of a subset of hair keratin genes by the NF-κB effector p65/RelA Differentiation · 2007 · 7 citations
    8. Expression and function of nuclear receptor co-activator 4: evidence of a potential role independent of co-activator activity Cellular and Molecular Life Sciences · 2012 · 26 citations
    9. Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation Development · 1999 · 990 citations
    10. Modulation of Vitamin D Receptor Activity by the Corepressor Hairless: Differential Effects of Hairless Isoforms Endocrinology · 2009 · 18 citations
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