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    Glossary Transcription Co-activator

    protein that helps activate gene expression by binding to transcription factors

    A transcription co-activator is a protein that helps turn on the expression of specific genes by binding to transcription factors, which are proteins that directly interact with DNA. While co-activators do not bind to DNA themselves, they facilitate the assembly of the transcription machinery, enhancing the efficiency of gene transcription. This process is crucial for regulating various biological functions, including hair growth and the response to conditions like alopecia.

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    1. The Transcriptional Co-Activator cAMP Response Element-Binding Protein-Binding Protein Is Expressed in Prostate Cancer and Enhances Androgen- and Anti-Androgen-Induced Androgen Receptor Function American Journal of Pathology · 2003 · 72 citations
    2. Lack of androgen receptor transcriptional activity in human keratinocytes Journal of dermatological science · 2000 · 30 citations
    3. Distinct use of super-enhancer elements controls cell type–specific CD25 transcription and function Science Immunology · 2023 · 10 citations
    4. Many Paths to Alopecia via Compromised Regeneration of Hair Follicle Stem Cells Journal of Investigative Dermatology · 2013 · 8 citations
    5. Langerin+ Dendritic Cells in Cutaneous Fibrosis: The TGF-β1 Signaling Axis Clinical Cosmetic and Investigational Dermatology · 2025
    6. Leptin and the skin: a new frontier Experimental Dermatology · 2009 · 108 citations
    7. Transcriptional activation of a subset of hair keratin genes by the NF-κB effector p65/RelA Differentiation · 2007 · 7 citations
    8. Expression and function of nuclear receptor co-activator 4: evidence of a potential role independent of co-activator activity Cellular and Molecular Life Sciences · 2012 · 26 citations
    9. Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation Development · 1999 · 990 citations
    10. Modulation of Vitamin D Receptor Activity by the Corepressor Hairless: Differential Effects of Hairless Isoforms Endocrinology · 2009 · 18 citations
    11. Probing androgen receptor co-factor selectivity profiles: a chemical tool to determine cross-talk between androgen receptor and β-catenin in vivo MedChemComm · 2013 · 1 citations
    12. Hairless Modulates Ligand-Dependent Activation of the Vitamin D Receptor-Retinoid X Receptor Heterodimer Biological & pharmaceutical bulletin · 2012 · 28 citations
    13. A role for the Tgf-β/Bmp co-receptor Endoglin in the molecular oscillator that regulates the hair follicle cycle bioRxiv (Cold Spring Harbor Laboratory) · 2017
    14. Forkhead/winged-helix transcription factor whn regulates hair keratin gene expression: Molecular analysis of theNude skin phenotype Developmental Dynamics · 2000 · 75 citations
    15. Stem Cell-Based Hair Cell Regeneration and Therapy in the Inner Ear Neuroscience Bulletin · 2023 · 26 citations
    16. Decision letter: Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis 2022
    17. A role for the Tgf-β/Bmp co-receptor Endoglin in the molecular oscillator that regulates the hair follicle cycle Journal of Molecular Cell Biology · 2018 · 26 citations
    18. Mechanisms that regulate androgen receptor transcriptional activity Carolina Digital Repository (University of North Carolina at Chapel Hill) · 2019
    19. Editor's evaluation: Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis 2022
    20. Genetically separable determinants of hair keratin gene expression Developmental Dynamics · 2000 · 27 citations
    21. The pioneer factor SOX9 competes for epigenetic factors to switch stem cell fates Nature cell biology · 2023 · 6 citations
    22. Evidence for a functional interaction of WNT10A and EBF1 in male-pattern baldness PLoS ONE · 2021 · 12 citations
    23. Role of vitamin D and calcium signaling in epidermal wound healing Journal of endocrinological investigation · 2022 · 15 citations
    24. Crystallization and preliminary X-ray analysis of the human androgen receptor ligand-binding domain with a coactivator-like peptide and selective androgen receptor modulators Acta crystallographica · 2008 · 1 citations
    25. GLI2-specific Transcriptional Activation of the Bone Morphogenetic Protein/Activin Antagonist Follistatin in Human Epidermal Cells 2008 · 39 citations
    26. Faculty Opinions recommendation of The vitamin D receptor is a Wnt effector that controls hair follicle differentiation and specifies tumor type in adult epidermis. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2008
    27. Coactivator MED1 Ablation in Keratinocytes Results in Hair-Cycling Defects and Epidermal Alterations 2011 · 41 citations
    28. SlPHL1, a MYB‐CC transcription factor identified from tomato, positively regulates the phosphate starvation response Physiologia Plantarum · 2021 · 11 citations
    29. Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells PLoS Biology · 2014 · 175 citations
    30. Hair Growth Stimulation Effect of Centipeda minima Extract: Identification of Active Compounds and Anagen-Activating Signaling Pathways Biomolecules · 2021 · 14 citations