High-Fat Diet Exacerbates Neutrophilic Folliculitis by Facilitating Sequential Chemokine Expressions by Keratinocytes and Neutrophils
TLDR A high-fat diet worsens neutrophilic folliculitis by increasing certain chemokines.
The study investigated the impact of a high-fat diet (HFD) on neutrophilic folliculitis using an obese mouse model and an irritant dermatitis model. It was found that HFD-fed obese mice showed dense neutrophil accumulation, forming microabscesses and pustules similar to neutrophilic folliculitis. The chemokine receptor CXCR2 was crucial for this neutrophil infiltration, as its absence prevented neutrophil accumulation. CXCL1 and CXCL2 chemokines were upregulated in HFD-fed mice, with CXCL1 produced by hair follicle keratinocytes and CXCL2 by epidermal neutrophils. Free fatty acids in HFD, such as palmitate and stearic acids, significantly increased CXCL1 and CXCL2 expression. The findings suggested that HFD exacerbated neutrophilic folliculitis in obesity by sequentially upregulating CXCR2 ligands in keratinocytes and neutrophils.
