Dynamic Interplay Between IL-1 and WNT Pathways in Regulating Dermal Adipocyte Lineage Cells During Skin Development and Wound Regeneration
June 2023
in “
Cell Reports
”
IL-1 WNT pathways dermal adipocyte lineage cells skin development wound healing single-cell RNA sequencing IL-1-NF-κB signaling adipogenesis WNT-β-catenin signaling neutrophils IL-1R-NF-κB-CREB axis lipolysis myofibroblast formation keloids dermal adipocyte plasticity interleukin-1 WNT signaling fat cells skin growth wound repair RNA sequencing NF-kappaB signaling fat cell formation beta-catenin signaling white blood cells CREB signaling fat breakdown scar tissue skin flexibility
Studysummary This study investigated dermal fibroblasts in mouse skin using single-cell RNA sequencing and identified signaling pathways that influence adipogenesis, finding that IL-1-NF-κB promotes, while WNT-β-catenin inhibits, the adipogenic potential of these cells, with implications for wound healing and scar formation.
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The study investigates the dynamic interaction between IL-1 and WNT pathways in dermal adipocyte lineage cells during skin development and wound healing. Using single-cell RNA sequencing on mouse skin, researchers identified distinct cell states and found that IL-1-NF-κB signaling promotes adipogenesis, while WNT-β-catenin signaling inhibits it. Neutrophils mediate wound-induced adipogenesis through the IL-1R-NF-κB-CREB axis. Conversely, WNT activation inhibits adipogenesis and promotes lipolysis and dedifferentiation, leading to myofibroblast formation. This sustained WNT activation is also observed in human keloids. The findings highlight molecular mechanisms of dermal adipocyte plasticity and suggest potential therapeutic targets for improving wound healing and reducing scar formation.
