Dynamic Interplay Between IL-1 and WNT Pathways in Regulating Dermal Adipocyte Lineage Cells During Skin Development and Wound Regeneration
June 2023
in “
Cell Reports
”
IL-1 WNT pathways dermal adipocyte lineage cells skin development wound healing single-cell RNA sequencing IL-1-NF-κB signaling adipogenesis WNT-β-catenin signaling neutrophils IL-1R-NF-κB-CREB axis lipolysis myofibroblast formation keloids dermal adipocyte plasticity interleukin-1 WNT signaling fat cells skin growth wound repair RNA sequencing NF-kappaB signaling fat cell formation beta-catenin signaling white blood cells CREB signaling fat breakdown scar tissue skin flexibility
Studysummary This study investigated dermal fibroblasts in mouse skin using single-cell RNA sequencing and identified signaling pathways that influence adipogenesis, finding that IL-1-NF-κB promotes, while WNT-β-catenin inhibits, the adipogenic potential of these cells, with implications for wound healing and scar formation.
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