Expression of Neutrophil Gelatinase-Associated Lipocalin in Calcium-Induced Keratinocyte Differentiation

January 2008 in “ Journal of Korean Medical Science ”

Jeung‐Hoon Lee, Kyung‐Chae Kye, Eun–Young Seo, Kyungmoon Lee, Sangkeun Lee, Jong-Soon Lim, Young‐Joon Seo, Chang Deok Kim, Jang-Kyu Park

neutrophil gelatinase-associated lipocalin NGAL keratinocyte differentiation calcium-induced differentiation epidermal hyperplasia psoriasis skin cancers hair follicles

TLDR NGAL may help maintain skin balance and is linked to skin disorders and cancers.

The study identified neutrophil gelatinase-associated lipocalin (NGAL) as a gene induced by calcium in keratinocyte differentiation. NGAL expression was significantly increased in vitro during calcium-induced differentiation, as shown by RT-PCR, Western blot, and ELISA. However, NGAL was not detected in normal skin tissue, except in hair follicles, suggesting differences between in vitro and in vivo conditions. Notably, NGAL expression was elevated in psoriasis-like inflammatory disorders and certain skin cancers, indicating a potential link to epidermal hyperplasia. These findings suggested that NGAL might play a crucial role in maintaining skin homeostasis.

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Research cited in this study

2 / 2 results

research Neutrophil Gelatinase-Associated Lipocalin Is a Marker for Dysregulated Keratinocyte Differentiation in Human Skin

96 citations , December 2002 in “Experimental dermatology”

NGAL indicates abnormal skin cell differentiation.

research Epithelial Barrier Function: Assembly and Structural Features of the Cornified Cell Envelope

425 citations , August 2002 in “BioEssays”

The cornified cell envelope forms a protective barrier in skin and hair, using specific proteins and lipids to maintain effectiveness.

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