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GlossaryLipocalin-2 (Neutrophil Gelatinase-Associated Lipocalin)

protein involved in immune response and iron regulation

Lipocalin-2 (LCN2), also known as Neutrophil Gelatinase-Associated Lipocalin (NGAL), is a protein involved in the body's immune response and iron metabolism. It helps to sequester iron, limiting bacterial growth during infections, and is also used as a biomarker for kidney injury and other inflammatory conditions.

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research Neutrophil Gelatinase-Associated Lipocalin Is a Marker for Dysregulated Keratinocyte Differentiation in Human Skin

96 citations, December 2002 in “Experimental dermatology”

NGAL indicates abnormal skin cell differentiation.

research Serum Lipocalin-2 as an Insulin Resistance Marker in Patients with Polycystic Ovary Syndrome

29 citations, March 2010 in “Journal of Endocrinological Investigation”

Lipocalin-2 levels are higher in women with PCOS and may indicate insulin resistance.

research Tcf3 Promotes Cell Migration and Wound Repair Through Regulation of Lipocalin 2

55 citations, June 2014 in “Nature Communications”

Tcf3 helps cells move and heal wounds by controlling lipocalin 2.

research Lab Quality Management and Methodology

January 2015 in “Indian Journal of Medical Biochemistry”

Men with early balding should be checked for metabolic syndrome, as there's a link between the two.

research Apoptosis May Explain the Pharmacological Mode of Action and Adverse Effects of Isotretinoin, Including Teratogenicity

66 citations, January 2017 in “Acta dermato-venereologica”

Isotretinoin's effects and side effects, like birth defects and depression, might be due to it causing cell death in various cells.

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community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.