Serum Lipocalin-2 as an Insulin Resistance Marker in Patients with Polycystic Ovary Syndrome

March 2010 in “ Journal of Endocrinological Investigation ”

Erman Cakal, Mesut Ozkaya, Yaprak Engin Üstün, Yusuf Üstün

lipocalin-2 insulin resistance polycystic ovary syndrome PCOS testosterone DHEAS HOMA-IR

TLDR Lipocalin-2 levels are higher in women with PCOS and may indicate insulin resistance.

In the 2010 study, researchers found that serum lipocalin-2 levels were significantly higher in women with polycystic ovary syndrome (PCOS) compared to a control group with normal ovulatory function, with levels of 54.26±15.58 ng/ml in the PCOS group versus 26.09±7.47 ng/ml in the control group. The study, which included 30 women with PCOS and 30 matched controls, also identified a strong correlation between lipocalin-2 levels and various markers of insulin resistance, such as insulin levels, HOMA-IR, testosterone, and DHEAS. A lipocalin-2 level greater than 39.54 ng/ml was found to predict insulin resistance with 81% sensitivity and 82.1% specificity. These findings suggest that serum lipocalin-2 could serve as a useful marker for insulin resistance in PCOS patients.

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