Nematic Fibrin Fibers Enabling Vascularized Thrombus Implants Facilitate Scarless Cutaneous Wound Healing

    April 2023 in “ Advanced materials ”
    Su Hyun Jung, Bong Hwan Jang, Soon-Young Kwon, Sung Jin Park, Tae‐Eun Park, Joo H. Kang
    Image of study
    TLDR Using blood-based implants improves skin healing and reduces scarring.
    The study presents implantable vascularized engineered thrombi (IVETs) using autologous whole blood to enhance skin wound healing by constructing robust microcapillary vessel networks at the wound site. Microfluidic shear stresses align bundled fibrin fibers and activate platelets, creating an optimal microenvironment for endothelial cell maturation and vascularization. Rodent dorsal skin wounds treated with IVETs showed superior wound closure rates (96.08 ± 1.58%), increased epidermis thickness, collagen deposition, hair follicle numbers, and reduced neutrophil infiltration due to enhanced microvascular circulation. Additionally, IVET treatment accelerates wound healing by recruiting M2 phenotype macrophages. The authors declare no conflict of interest.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    5 / 5 results

      community Hairloss after doing PRF treatment

      in Treatment  2 upvotes 1 year ago
      The conversation is about the potential risk of permanent hair loss from PRP (platelet rich plasma) treatments and whether PRF (platelet rich fibrin) carries the same risk. The user is seeking information on this topic.

      community Here is my hair regrowth plan

      in Treatment  4 upvotes 4 years ago
      The user's hair regrowth plan includes topical treatments (RU58841, azelaic acid, ketoconazole), oral supplements (Gia Herbs, castor oil), microneedling, PTD-DBM peptide with valproic acid, red light therapy, inversion table with scalp massage, and platelet-rich fibrin injections. Commenters suggest that finasteride and minoxidil are essential treatments for male pattern hair loss, which are missing from the plan.

      community I need your help - transplant after care

      in Transplants  1 upvotes 2 months ago
      The user is concerned about post-hair transplant care, specifically regarding the use of a bandana, minoxidil, and tretinoin. They are advised to consider finasteride and possibly adjust the minoxidil dosage.

      community Anything you use without scientific backing, just trusting your gut?

      in Research/Science  12 upvotes 2 years ago
      The conversation discusses using peppermint oil for hair loss, with one user applying it undiluted to the scalp and another combining it with finasteride and microneedling. Some believe in its effectiveness despite limited scientific evidence, and also mention rosemary oil as potentially beneficial.

    Similar Research

    5 / 1000+ results