Nematic Fibrin Fibers Enabling Vascularized Thrombus Implants Facilitate Scarless Cutaneous Wound Healing

    April 2023 in “ Advanced materials ”
    Su Hyun Jung, Bong Hwan Jang, Soon-Young Kwon, Sung Jin Park, Tae‐Eun Park, Joo H. Kang
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    TLDR Using blood-based implants improves skin healing and reduces scarring.
    The study presents implantable vascularized engineered thrombi (IVETs) using autologous whole blood to enhance skin wound healing by constructing robust microcapillary vessel networks at the wound site. Microfluidic shear stresses align bundled fibrin fibers and activate platelets, creating an optimal microenvironment for endothelial cell maturation and vascularization. Rodent dorsal skin wounds treated with IVETs showed superior wound closure rates (96.08 ± 1.58%), increased epidermis thickness, collagen deposition, hair follicle numbers, and reduced neutrophil infiltration due to enhanced microvascular circulation. Additionally, IVET treatment accelerates wound healing by recruiting M2 phenotype macrophages. The authors declare no conflict of interest.
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