Mechanisms of Tolerance and Potential Therapeutic Interventions in Alopecia Areata

November 2017 in “ Pharmacology & therapeutics ”

Gabriel Skogberg, Sonya Jackson, Annika Åstrand

Alopecia Areata autoimmune disorder immune tolerance central tolerance peripheral tolerance gut permeability local skin changes AA

TLDR Targeting immune tolerance issues in Alopecia Areata could restore hair growth and maintain remission.

This review discussed the mechanisms of compromised immune tolerance in Alopecia Areata (AA), an autoimmune disorder linked to other autoimmune diseases. It highlighted that AA involves a break in central and peripheral tolerance, increased gut permeability, and local skin changes. The review suggested that targeting these tolerance breaks could lead to effective treatments to restore hair growth and maintain remission.

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