Histone Deacetylase 1 in Patients With Alopecia Areata and Acne Vulgaris: An Epigenetic Alteration

January 2022 in “ Australasian Journal of Dermatology ”

Heba A. Abdelkader, Iman M. Amin, Laila Ahmed Rashed, Maha Samir, Marwa Ezzat

histone deacetylase 1 alopecia areata acne vulgaris HDAC1 HDAC inhibitors epigenetic alteration

Studysummary This study found that serum HDAC1 levels are significantly higher in patients with alopecia areata compared to those with acne vulgaris and healthy controls, suggesting potential therapeutic opportunities for HDAC inhibitors. Our plain-language summary of this paper — not a Tressless recommendation.

This study investigated the deregulation of histone deacetylase 1 (HDAC1) in patients with alopecia areata (AA) and acne vulgaris. Conducted as a case-control study with 76 participants, including 25 with patchy AA, 26 with acne vulgaris, and 25 healthy controls, the research measured HDAC1 levels using ELISA. Results showed a significant difference in serum HDAC1 levels among the groups, with the highest levels observed in the AA group. The findings suggested that HDAC1 deregulation might offer a potential therapeutic target for HDAC inhibitors in treating these conditions.

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