Hair Follicle-Related MicroRNA-34a Serum Expression and rs2666433A/G Variant in Patients with Alopecia: A Cross-Sectional Analysis

April 2022 in “ Biomolecules ”

Shymaa Ahmed Maher, Nader Ismail, Eman A. Toraih, Alaa Hamed Habib, Nawal S. Gouda, Amal H. A. Gomaa, Manal S. Fawzy, Ghada M. Helal

microRNA-34a MIR-34A rs2666433A/G variant alopecia areata AA serum miR-34a levels A/A genotype autoimmune comorbidities SLE vitiligo miR-34a lupus

TLDR Higher miR-34a levels and the A variant of the MIR-34A gene are linked to increased risk and severity of alopecia areata.

This study analyzed the association between the microRNA-34a gene (MIR-34A) rs2666433A/G variant and alopecia areata (AA) in 480 participants (240 cases and 240 controls). It found a higher frequency of the A variant in AA patients, with significant associations under various genetic models. Serum miR-34a levels were significantly upregulated in AA patients, especially those with the A/A genotype, and were linked to more severe disease and autoimmune comorbidities like SLE and vitiligo. The study concludes that the MIR34A rs2666433 (A/G) variant and elevated miR-34a levels are associated with increased risk and severity of AA, suggesting miR-34a as a potential molecular marker for AA.

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