Genetic Analysis of a Novel Antioxidant Multi-Target Iron Chelator, M30, Protecting Against Chemotherapy-Induced Alopecia in Mice

    February 2019 in “ BMC cancer
    Young-Cheol Lim, Il Tae Kim, Sang Moo Lim, Jin Su Kim
    Image of study
    TLDR M30 is a promising treatment for preventing hair loss during chemotherapy.
    The study from 2019 investigated the effectiveness of a novel antioxidant multi-target iron chelator, M30, in preventing chemotherapy-induced alopecia in mice. The research involved C57BL/6 mice treated with cyclophosphamide to induce hair loss, which were then administered M30. Results showed that M30 enhanced hair growth and prevented the abnormal hair changes typically caused by cyclophosphamide. Gene expression profiles from skin biopsies identified five key genes (Tnfrsf19, Ercc2, Lama5, Ctsl, and Per1) associated with various aspects of hair growth and follicle development that were affected by the treatment. The study concluded that M30 is a promising therapy for preventing hair loss caused by chemotherapy and highlighted the potential role of the identified genes in hair cycle regulation and follicle maturation.
    Discuss this study in the Community →

    Research cited in this study

    8 / 8 results

    Related Community Posts Join

    6 / 111 results

      community M30, month 2 of dutasteride and minoxidil

      in Progress Pictures  254 upvotes 2 days ago
      A user shared their two-month progress using dutasteride, minoxidil, ketoconazole shampoo, and tretinoin cream for hair loss, reporting no side effects and increased sex drive. Other users discussed their experiences with similar treatments, including finasteride and oral minoxidil, and debated the effectiveness of microneedling.

      community M30, month 1 of dutasteride and minoxidil

      in Is this regrowth?  22 upvotes 1 month ago
      A 30-year-old male is using a regimen of dutasteride, minoxidil, ketoconazole shampoo, tretinoin cream, and microneedling for hair regrowth. He reports no side effects and has noticed visual improvement after one month.

      community M30 | Sharing my 15 month progress with ya'll!

      in Progress Pictures  151 upvotes 4 months ago
      A user shared their 15-month hair regrowth progress using finasteride, minoxidil, biotin, increased protein intake, and derma rolling. They also improved their lifestyle by working out, quitting smoking, drinking less, and getting better sleep.

    Related Research

    5 / 5 results