Genetic Analysis of a Novel Antioxidant Multi-Target Iron Chelator, M30, Protecting Against Chemotherapy-Induced Alopecia in Mice

February 2019 in “ BMC cancer ”

Young-Cheol Lim, Il Tae Kim, Sang Moo Lim, Jin Su Kim

M30 antioxidant iron chelator chemotherapy-induced alopecia C57BL/6 mice cyclophosphamide hair growth gene expression Tnfrsf19 Ercc2 Lama5 Ctsl Per1 hair cycle regulation follicle maturation chemotherapy-induced hair loss hair loss hair cycle follicle development

TLDR M30 is a promising treatment for preventing hair loss during chemotherapy.

The study from 2019 investigated the effectiveness of a novel antioxidant multi-target iron chelator, M30, in preventing chemotherapy-induced alopecia in mice. The research involved C57BL/6 mice treated with cyclophosphamide to induce hair loss, which were then administered M30. Results showed that M30 enhanced hair growth and prevented the abnormal hair changes typically caused by cyclophosphamide. Gene expression profiles from skin biopsies identified five key genes (Tnfrsf19, Ercc2, Lama5, Ctsl, and Per1) associated with various aspects of hair growth and follicle development that were affected by the treatment. The study concluded that M30 is a promising therapy for preventing hair loss caused by chemotherapy and highlighted the potential role of the identified genes in hair cycle regulation and follicle maturation.

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research Treatment of Chemotherapy-Induced Alopecia

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The document concludes that assessing hair follicle damage due to cyclophosphamide in mice involves analyzing structural changes and suggests a scoring system for standardized evaluation.

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5 / 5 results

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research Protection Against Chemotherapy-Induced Alopecia: Targeting ATP-Binding Cassette Transporters in the Hair Follicle

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Increasing ABC transporters in hair follicles may prevent chemotherapy-induced hair loss.

research Pathobiology of Chemotherapy-Induced Hair Loss

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research Towards a Molecular Understanding of Hair Loss and Its Treatment

236 citations , July 2001 in “Trends in Molecular Medicine”

Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.