Protection Against Cytosine Arabinoside-Induced Alopecia by Minoxidil in a Rat Animal Model

July 1995 in “ International Journal of Dermatology ”

A. Hussein

minoxidil cytosine arabinoside chemotherapy-induced alopecia Rogaine

TLDR Minoxidil helps prevent hair loss from chemotherapy in rats.

In 1995, a study found that minoxidil can protect against hair loss induced by the chemotherapy drug cytosine arabinoside in a rat animal model. The researchers suggest that minoxidil may be a useful adjunct therapy for cancer patients undergoing chemotherapy to prevent hair loss. The mechanism of action of minoxidil in its protection against chemotherapy-induced alopecia is currently unknown and under investigation.

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Research cited in this study

9 / 9 results

research Chemotherapy-Induced Alopecia

52 citations , May 1993 in “Southern Medical Journal”

Imuvert can prevent some chemotherapy-induced hair loss.

research Quantitative Estimation of Hair Growth: Androgenetic Alopecia in Women and the Effect of Minoxidil

85 citations , December 1990 in “Journal of Investigative Dermatology”

Minoxidil promotes hair growth in women with early-stage alopecia.

research Relationship Between Contact Time of Applied Dose and Percutaneous Absorption of Minoxidil From a Topical Solution

25 citations , June 1990 in “Journal of Pharmaceutical Sciences”

Longer contact time increases minoxidil absorption, but doesn't affect metabolism.

research Five-Year Follow-Up of Men with Androgenetic Alopecia Treated with Topical Minoxidil

70 citations , April 1990 in “Journal of The American Academy of Dermatology”

Minoxidil treatment increased hair growth for up to 5 years, requiring twice daily application.

research Minoxidil Stimulates Mouse Vibrissae Follicles in Organ Culture

121 citations , March 1989 in “Journal of Investigative Dermatology”

Minoxidil can help grow hair in mice by making cells grow and improving hair quality. More research needed.

research Topical Minoxidil: Cardiac Effects in Bald Men

45 citations , October 1988 in “British Journal of Clinical Pharmacology”

Using topical minoxidil for baldness can cause heart problems, especially in those with heart disease.

research Hair Follicle Biology and Topical Minoxidil: Possible Mechanisms of Action

37 citations , January 1987 in “Dermatology”

Minoxidil stimulates hair growth by increasing hair thickness and prolonging growth phase.

research Topical Minoxidil Reduces Blood Pressure

17 citations , March 1985 in “Journal of The American Academy of Dermatology”

Minoxidil can lower blood pressure in some people.

Minoxidil Stimulates Cutaneous Blood Flow in Human Balding Scalps: Pharmacodynamics Measured by Laser Doppler Velocimetry and Photopulse Plethysmography

research Minoxidil Stimulates Cutaneous Blood Flow in Human Balding Scalps: Pharmacodynamics Measured by Laser Doppler Velocimetry and Photopulse Plethysmography

137 citations , May 1984 in “Journal of Investigative Dermatology”

Minoxidil increases blood flow in balding scalps, possibly reversing hair loss.

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community Prolactin’s role in antitumor activity of the immune system – a safety concern for HMI-115?

in Research/Science 3 upvotes 2 years ago

Hair loss discussion includes treatments Minoxidil, Finasteride, and RU58841. Prolactin's role in immune system's antitumor activity raises safety concerns for HMI-115.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community I bought a microscope, how does my scalp/hairs look? I've been suffering diffuse thinning and hair loss after covid and never recovered (2 yrs ago) I eat healthy, in shape and workout.

in Progress Pictures 87 upvotes 1 year ago

A person with hair loss since COVID-19 is considering treatments like finasteride and minoxidil but is hesitant due to potential side effects. Suggestions include visiting a dermatologist, using a ketoconazole shampoo, and considering that post-COVID hair loss might be an autoimmune response.

community Comprehensive Microneedling Guide

in Microneedling 290 upvotes 3 years ago

Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

community Has anyone here actually gotten positive results using minoxidil + tretinoin?

in Minoxidil 7 upvotes 2 days ago

Combining minoxidil with tretinoin appears to enhance hair growth for some users, with several reporting better results than using minoxidil alone. Some users also incorporate other treatments like dutasteride, latanoprost, and microneedling for improved outcomes.

community Is there an effective growth stimulator for people who don't tolerate Minoxidil?

in Minoxidil 4 upvotes 3 days ago

The conversation is about finding an alternative hair growth stimulator for someone who cannot use Minoxidil due to heart issues. The person is currently using topical dutasteride, azelaic acid, and occasional microneedling, and is considering options like retinyl palmitate, latanoprost, certizine, or tadalafil.

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research Original Article: Study on the Clinical Characteristics of Chemotherapy-Induced Permanent Alopecia

December 2013 in “대한피부과학회지”

Chemotherapy can cause permanent hair loss.

research Low-Level Laser Treatment Accelerated Hair Regrowth in a Rat Model of Chemotherapy-Induced Alopecia

43 citations , June 2012 in “Lasers in Medical Science”

Low-level laser treatment helped rats regrow hair faster after chemotherapy.

research Treatment of Chemotherapy-Induced Alopecia

64 citations , July 2011 in “Dermatologic Therapy”

Scalp cooling can prevent chemotherapy-induced hair loss, and certain treatments can speed up hair regrowth, but more research is needed for better treatments.

Permanent Alopecia Following Chemotherapy and Bone Marrow Transplantation

research Chemotherapy-Induced Alopecia

52 citations , May 1993 in “Southern Medical Journal”

Imuvert can prevent some chemotherapy-induced hair loss.

Protection Against Cytosine Arabinoside-Induced Alopecia by Minoxidil in a Rat Animal Model

Research cited in this study

research Chemotherapy-Induced Alopecia

research Quantitative Estimation of Hair Growth: Androgenetic Alopecia in Women and the Effect of Minoxidil

research Relationship Between Contact Time of Applied Dose and Percutaneous Absorption of Minoxidil From a Topical Solution

research Five-Year Follow-Up of Men with Androgenetic Alopecia Treated with Topical Minoxidil

research Minoxidil Stimulates Mouse Vibrissae Follicles in Organ Culture

research Topical Minoxidil: Cardiac Effects in Bald Men

research Hair Follicle Biology and Topical Minoxidil: Possible Mechanisms of Action

research Topical Minoxidil Reduces Blood Pressure

research Minoxidil Stimulates Cutaneous Blood Flow in Human Balding Scalps: Pharmacodynamics Measured by Laser Doppler Velocimetry and Photopulse Plethysmography

Related Community Posts Join

community Prolactin’s role in antitumor activity of the immune system – a safety concern for HMI-115?

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community I bought a microscope, how does my scalp/hairs look? I've been suffering diffuse thinning and hair loss after covid and never recovered (2 yrs ago) I eat healthy, in shape and workout.

community Comprehensive Microneedling Guide

community Has anyone here actually gotten positive results using minoxidil + tretinoin?

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Related Research

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research Protection Against Cytosine Arabinoside-Induced Alopecia by Minoxidil in a Rat Animal Model

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