Protection Against Cytosine Arabinoside-Induced Alopecia by Minoxidil in a Rat Animal Model

July 1995 in “ International Journal of Dermatology ”

A. Hussein

minoxidil cytosine arabinoside chemotherapy-induced alopecia Rogaine

TLDR Minoxidil helps prevent hair loss from chemotherapy in rats.

In 1995, a study found that minoxidil can protect against hair loss induced by the chemotherapy drug cytosine arabinoside in a rat animal model. The researchers suggest that minoxidil may be a useful adjunct therapy for cancer patients undergoing chemotherapy to prevent hair loss. The mechanism of action of minoxidil in its protection against chemotherapy-induced alopecia is currently unknown and under investigation.

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Research cited in this study

8 / 8 results

research Quantitative Estimation of Hair Growth: Androgenetic Alopecia in Women and the Effect of Minoxidil

85 citations, December 1990 in “Journal of Investigative Dermatology”

Minoxidil promotes hair growth in women with early-stage alopecia.

research Relationship Between Contact Time of Applied Dose and Percutaneous Absorption of Minoxidil From a Topical Solution

25 citations, June 1990 in “Journal of Pharmaceutical Sciences”

Longer contact time increases minoxidil absorption, but doesn't affect metabolism.

research Five-Year Follow-Up of Men with Androgenetic Alopecia Treated with Topical Minoxidil

70 citations, April 1990 in “Journal of The American Academy of Dermatology”

Minoxidil treatment increased hair growth for up to 5 years, requiring twice daily application.

research Minoxidil Stimulates Mouse Vibrissae Follicles in Organ Culture

121 citations, March 1989 in “Journal of Investigative Dermatology”

Minoxidil can help grow hair in mice by making cells grow and improving hair quality. More research needed.

research Topical Minoxidil: Cardiac Effects in Bald Men

45 citations, October 1988 in “British Journal of Clinical Pharmacology”

Using topical minoxidil for baldness can cause heart problems, especially in those with heart disease.

research Hair Follicle Biology and Topical Minoxidil: Possible Mechanisms of Action

37 citations, January 1987 in “Dermatology”

Minoxidil stimulates hair growth by increasing hair thickness and prolonging growth phase.

research Topical Minoxidil Reduces Blood Pressure

17 citations, March 1985 in “Journal of The American Academy of Dermatology”

Minoxidil can lower blood pressure in some people.

Minoxidil Stimulates Cutaneous Blood Flow in Human Balding Scalps: Pharmacodynamics Measured by Laser Doppler Velocimetry and Photopulse Plethysmography

research Minoxidil Stimulates Cutaneous Blood Flow in Human Balding Scalps: Pharmacodynamics Measured by Laser Doppler Velocimetry and Photopulse Plethysmography

137 citations, May 1984 in “Journal of Investigative Dermatology”

Minoxidil increases blood flow in balding scalps, possibly reversing hair loss.

Related Research

6 / 6 results

research Original Article: Study on the Clinical Characteristics of Chemotherapy-Induced Permanent Alopecia

December 2013 in “대한피부과학회지”

Chemotherapy can cause permanent hair loss.

research Low-Level Laser Treatment Accelerated Hair Regrowth in a Rat Model of Chemotherapy-Induced Alopecia

43 citations, June 2012 in “Lasers in Medical Science”

Low-level laser treatment helped rats regrow hair faster after chemotherapy.

research Treatment of Chemotherapy-Induced Alopecia

64 citations, July 2011 in “Dermatologic Therapy”

Scalp cooling can prevent chemotherapy-induced hair loss, and certain treatments can speed up hair regrowth, but more research is needed for better treatments.

Permanent Alopecia Following Chemotherapy and Bone Marrow Transplantation

Protection Against Cytosine Arabinoside-Induced Alopecia by Minoxidil in a Rat Animal Model

Research cited in this study

research Quantitative Estimation of Hair Growth: Androgenetic Alopecia in Women and the Effect of Minoxidil

research Relationship Between Contact Time of Applied Dose and Percutaneous Absorption of Minoxidil From a Topical Solution

research Five-Year Follow-Up of Men with Androgenetic Alopecia Treated with Topical Minoxidil

research Minoxidil Stimulates Mouse Vibrissae Follicles in Organ Culture

research Topical Minoxidil: Cardiac Effects in Bald Men

research Hair Follicle Biology and Topical Minoxidil: Possible Mechanisms of Action

research Topical Minoxidil Reduces Blood Pressure

research Minoxidil Stimulates Cutaneous Blood Flow in Human Balding Scalps: Pharmacodynamics Measured by Laser Doppler Velocimetry and Photopulse Plethysmography

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