ER71/ETV2 Promotes Hair Regeneration from Chemotherapy-Induced Hair Loss by Enhancing Angiogenesis

September 2021 in “ Biomolecules & Therapeutics ”

Tae-Jin Lee, Hee‐Kyoung Kang, Jeffrey C. Berry, Hong‐Gu Joo, Changwon Park, Mark J. Miller, Kyunghee Choi

ER71 ETV2 angiogenesis hair regeneration chemotherapy-induced hair loss 5-fluorouracil hair follicles anagen induction lentiviral injection capillary density 5-FU

TLDR The protein ER71/ETV2 helps regrow hair after chemotherapy by improving the growth of new blood vessels.

The study found that the protein ER71/ETV2 can aid in hair regeneration after hair loss caused by chemotherapy by enhancing angiogenesis, the process of forming new blood vessels. Overexpression of ER71/ETV2 in mice led to an increase in hair follicles and hair regrowth after chemotherapy-induced hair loss. The chemotherapeutic agent 5-fluorouracil (5-FU) was found to cause hair follicle vascular injury, leading to delayed hair regrowth. However, the ETV2 factor promoted angiogenesis and hair regrowth in mice treated with 5-FU. Mice lacking ETV2 showed a significant reduction in capillary density, anagen induction, and hair restoration when treated with 5-FU. Conversely, mice receiving lentiviral ETV2 injection after 5-FU treatment showed significantly improved anagen induction and hair regrowth. The study concluded that strategies to regenerate vessels may improve hair regrowth after chemotherapeutic treatment.

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