Role of DNA Methylation in the Pathogenesis of Skin Disorders: Mechanisms, Inhibitors of Methylation-Related Enzyme, and Molecular Docking Studies

January 2025 in “ BioMed Research International ”

Anchal Rani, Gagandeep Kaur, R. Kumar, Rohan Samir Kumar Sachan, Mukesh Kumar, Harsh Sable, Abdel Rahman Al-Tawaha, Shahid Malik, Arun Karnwal, Tabarak Malik

DNA methylation atopic dermatitis androgenetic alopecia psoriasis DNMT inhibitors 5-aza-2′-deoxycytidine dihydromyricetin miRNAs molecular docking inflammatory skin disorders degenerative skin disorders melanoma Decitabine

TLDR Targeting DNA methylation can help treat skin disorders and cancers.

The document explores the significant role of DNA methylation in the pathogenesis of various skin disorders, including atopic dermatitis, androgenetic alopecia, and psoriasis, among others. DNA methylation affects gene expression and cellular differentiation, contributing to inflammatory reactions and disease progression. The study highlights the potential of DNMT inhibitors, such as 5-aza-2′-deoxycytidine and dihydromyricetin, as therapeutic agents to modulate DNA methylation and alleviate symptoms. Molecular docking and computational modeling have advanced the identification of DNMT inhibitors, suggesting their application in treating inflammatory and degenerative skin disorders. Additionally, the regulation of DNA methylation by miRNAs is crucial in skin pathology, and targeting these pathways could offer new treatment strategies. The findings underscore the potential of methylation-targeted therapies in precision medicine, particularly for inflammatory skin conditions and cancers like melanoma.

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Research cited in this study

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