The Association Between HDAC9 Gene Polymorphisms and Stroke Risk in the Chinese Population: A Meta-Analysis

The meta-analysis investigated the link between HDAC9 gene polymorphisms and stroke risk in the Chinese population, analyzing data from six case-control studies with 2,356 stroke patients and 3,420 healthy controls. The study found that the rs2107595 polymorphism was significantly associated with an increased risk of stroke, while the rs2389995 polymorphism was associated with a decreased risk. No significant association was found for the rs2240419 polymorphism. Despite limitations such as small sample sizes and potential heterogeneity, the analysis concluded that the T allele of rs2107595 is a risk factor for stroke, the G allele of rs2389995 is protective against stroke, and the rs2240419 polymorphism does not significantly affect stroke risk in the Chinese population. Further research is needed to confirm these findings and consider gene-environment interactions.