Sodium Valproate Improves Skin Flap Survival via Gamma-Aminobutyric Acid and Histone Deacetylase Inhibitory System

    October 2019 in “ ˜The œJournal of surgical research/Journal of surgical research ”
    Moein Ala, Razieh Mohammad Jafari, Hossein Nematian, Mohammad Reza Ganjedanesh, Ahmad Reza Dehpour
    TLDR Sodium valproate helps skin healing by affecting GABA and histone deacetylase.
    The study investigated the effects of sodium valproate on skin flap survival in rats, focusing on its mechanisms involving gamma-aminobutyric acid (GABA) and histone deacetylase (HDAC) inhibition. Acute treatment with sodium valproate (100 mg/kg) significantly reduced skin necrosis, while chronic treatment also showed reduced necrosis and faster healing compared to controls. The protective effects were mediated through GABA and HDAC pathways, as evidenced by the reversal of benefits when combined with bicuculline (a GABAA antagonist) or trichostatin A (an HDAC inhibitor). The findings suggested that sodium valproate could enhance skin healing and reduce necrosis through these mechanisms.
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