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research Sodium Valproate Improves Skin Flap Survival via Gamma-Aminobutyric Acid and Histone Deacetylase Inhibitory System

8 citations , October 2019 in “The Journal of surgical research/Journal of surgical research”

This study demonstrated that sodium valproate accelerates skin healing and reduces necrosis in a rat model of skin flap potentially through mechanisms involving GABA and histone deacetylase pathways.

research γ-Aminobutyric acid promotes the inhibition of hair growth induced by chronic restraint stress

1 citations , January 2023 in “Life sciences”

This study demonstrated that elevated GABA levels can worsen stress-induced hair growth inhibition in mice, while GABAA antagonists like ginkgolide A may help alleviate these effects.

research Antidepressant-like effect of fluoxetine may depend on translocator protein activity and pretest session duration in forced swimming test in mice

7 citations , October 2017 in “Behavioural Pharmacology”

This study found that the antidepressant-like effect of fluoxetine in mice was only observed when a 5-minute pretest session was conducted, and this effect was blocked by the TSPO antagonist PK11195.

research ABSTRACTS—SYMPOSIA

June 2008 in “Alcoholism Clinical and Experimental Research”

This study discusses how chronic ethanol exposure and withdrawal affect GABAA receptor subunit expression and function, finding that some changes can be selectively blocked by certain drugs like diazepam and finasteride.

research Participation of GABAA, GABAB receptors and neurosteroids in toluene-induced hypothermia: Evidence of concentration-dependent differences in the mechanism of action

17 citations , October 2012 in “European Journal of Pharmacology”

This study found that inhaling toluene reduces core temperature in mice, with GABA receptors and neurosteroids involved at 4000 ppm, but different mechanisms contributing at 6000 ppm.

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community 5 years post hair transplant, 3 months on minoxidil only

326 upvotes 9 months ago

The user had a hair transplant five years ago and started using minoxidil three months ago. Commenters recommend adding finasteride or other DHT blockers to prevent further hair loss and maintain results.

community Dutasteride users- when and how did it go for you?

in Finasteride/Dutasteride 58 upvotes 9 months ago

Dutasteride can stabilize or improve hair loss but may cause side effects like depression and anxiety. Users often switch from finasteride to dutasteride for stronger results, with varied experiences in shedding and regrowth.

community Dutasteride mental side effect surprised me

59 upvotes 1 week ago

Switching from finasteride and topical minoxidil to a dutasteride and oral minoxidil combination caused severe anxiety and sleep issues. Users suggest that oral minoxidil may be the cause, and recommend alternatives like magnesium supplements or switching back to previous treatments.

community Why do most of you choose finasteride instead of dutasteride?

in Finasteride/Dutasteride 115 upvotes 1 year ago

Finasteride is preferred over dutasteride due to its longer history, more research, and FDA approval, despite dutasteride being more potent. Users report varied side effects, influencing personal treatment choices.

community Why does this industry still revolve around 5-AR inhibitors?

40 upvotes 5 years ago

Hair loss treatments still rely heavily on minoxidil, finasteride, and RU58841, with little innovation. Future treatments like stem cell therapy and RNA technology show promise but are not yet available.

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