Gamma-Aminobutyric Acid Promotes the Inhibition of Hair Growth Induced by Chronic Restraint Stress

    January 2023 in “ Life sciences ”
    Xuewen Wang, Yixin Su, Zhenying Cai, Yuanye Xu, Xia Wu, Mus’ab Al Rudaisat, Chunting Hua, Siji Chen, Lihua Li, Hao Cheng, Yinjing Song, Qiang Zhou
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    TLDR GABA contributes to stress-related hair loss, and ginkgolide A may help treat it.
    The study investigated the role of γ-Aminobutyric acid (GABA) in hair growth inhibition induced by chronic restraint stress (CRS) using C57BL/6 male mice. RNA sequencing analysis revealed significant changes in genes related to GABA receptors after stress induction, with increased GABA concentrations in serum and skin tissue. The findings suggest that elevated GABA levels promote CRS-induced hair growth inhibition by downregulating the cell cycle of dermal papilla (DP) cells. The study concludes that the GABAA receptor could be a promising therapeutic target for stress-induced hair loss.
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