Gamma-Aminobutyric Acid Promotes the Inhibition of Hair Growth Induced by Chronic Restraint Stress
March 2023
in “
Life sciences
”
TLDR GABA contributes to stress-related hair loss, and ginkgolide A may help treat it.
This study explored the role of γ-aminobutyric acid (GABA) in stress-related hair loss by examining its effects on mice subjected to chronic restraint stress (CRS). The researchers found that CRS led to increased levels of GABA in the skin and serum, which correlated with inhibited hair growth. This inhibition was exacerbated by additional GABA and reduced by GABAA antagonists like picrotoxin and ginkgolide A. RNA sequencing showed that GABA treatment downregulated genes involved in the cell cycle, DNA replication, and metabolism in dermal papilla (DP) cells, which are crucial for hair growth. Ginkgolide A, derived from Ginkgo biloba, was found to promote the cell cycle in DP cells, suggesting its potential as a treatment for hair loss. The study concludes that GABA contributes to hair growth inhibition under stress and identifies ginkgolide A as a possible therapeutic agent.
View this study on sciencedirect.com →
Cited in this study
23 / NoResults
research Integrated Transcriptomics and Metabolomics Analyses of Stress-Induced Murine Hair Follicle Growth Inhibition
Chronic stress in mice changes skin metabolism and gene expression, leading to hair loss.
research Telogen Effluvium: A Review of the Science and Current Obstacles
The document concludes that we need more research to understand Telogen Effluvium and find effective treatments.
research Increased Expression of Zyxin and Its Potential Function in Androgenetic Alopecia
research Human-Derived Immortalized Dermal Papilla Cells With Constant Expression of Androgen Receptor
Researchers created immortal human skin cells with constant testosterone receptor activity to study hair loss and test treatments.
research Alcohol Extract from Vernonia Anthelmintica Seed Counteracts Stress-Induced Murine Hair Follicle Growth Inhibition
Alcohol extract from Vernonia anthelmintica seeds may help treat stress-related hair loss.
research Stimulation of Hair Growth by Small Molecules That Activate Autophagy
Certain small molecules can promote hair growth by activating a cellular cleanup process called autophagy.
research Tissue engineering of human hair follicles using a biomimetic developmental approach
Researchers created human hair follicles using a new method that could help treat hair loss.
research Review of Hair Follicle Dermal Papilla cells as in vitro screening model for hair growth
Dermal Papilla cells are a promising tool for evaluating hair growth treatments.
research Valproate: It's effects on hair
Valproate can cause hair loss and changes in hair appearance, but may help regrow hair when applied topically.
research Minoxidil Induction of VEGF Is Mediated by Inhibition of HIF-Prolyl Hydroxylase
Minoxidil boosts hair growth by increasing blood flow and nutrients to hair follicles.
research Health-related quality of life (HRQoL) among patients with alopecia areata (AA): A systematic review
People with alopecia areata, a skin disease, generally have a poor quality of life, especially if more of their scalp is affected.
research Stress-related skin disorders
Stress can worsen skin conditions by affecting hormone levels and immune response.
research Alopecia areata and health-related quality of life: a systematic review and meta-analysis
Alopecia areata significantly lowers the quality of life, especially in emotional and mental health aspects.
research Cosmetic side effects of antiepileptic drugs in adults with epilepsy
Some antiepileptic drugs can cause weight gain and hair loss, especially in women.
research Differential effects of caffeine on hair shaft elongation, matrix and outer root sheath keratinocyte proliferation, and transforming growth factor‐β2/insulin‐like growth factor‐1‐mediated regulation of the hair cycle in male and female human hair folliclesin vitro
Caffeine affects hair growth and health differently in men and women.
research Hair Growth‐Promoting Effect of Carthamus tinctorius Floret Extract
Safflower (Carthamus tinctorius) extract helps hair grow and could be used in hair products.
research Health Status, Coping Strategies, and Alexithymia in Subjects with Androgenetic Alopecia
People with hair loss feel more depressed and anxious, especially women, and need help managing emotions and beliefs about their condition.
research Hair Growth Activity of Crataegus pinnatifida on C57BL/6 Mouse Model
Crataegus pinnatifida extract may help increase hair growth and thickness in mice.
research De Novo Production of Dermal Papilla Cells during the Anagen Phase of the Hair Cycle
New cells are added to the hair's dermal papilla during the active growth phase.
research β-catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair
β-catenin in the dermal papilla is crucial for normal hair growth and repair.
research Promotion effect of norgalanthamine, a component of Crinum asiaticum, on hair growth
Norgalanthamine from Crinum asiaticum may help hair grow.
research The hair growth promoting effect of extract and its molecular regulation
Asiasari radix extract promotes hair growth and increases protein synthesis and cell proliferation.
research Control of hair growth and follicle size by VEGF-mediated angiogenesis
VEGF helps hair grow and determines follicle size by increasing blood vessel growth.
Related
3 / NoResults
research Diffuse Hair Loss
The document's conclusion cannot be summarized because it is not readable or understandable.
research Hair Loss
The document's conclusion about hair loss cannot be determined.
research A review on Hair Loss & Damage
The article concludes that understanding the causes of hair loss and using continuous treatments like minoxidil and finasteride can help manage it, despite potential side effects.