Sodium Divalproate in Low Alternating Daily Doses for Migraine Prevention: A Retrospective Study

    July 2019 in “ Headache The Journal of Head and Face Pain ”
    Abouch Valenty Krymchantowski, Ana Gabriela Krymchantowski, Carla Jevoux
    TLDR Low alternating doses of sodium divalproate reduced migraine frequency but caused weight gain.
    This retrospective study evaluated the efficacy, adherence, and tolerability of sodium divalproate (SD) in low alternating daily doses (250 mg and 500 mg) for migraine prevention in 68 patients. Results showed a reduction in headache frequency from 8.2 to 5.1 days/month at 2 months (73.5% adherence) and to 4.2 days/month at 4 months (61.8% adherence). Weight gain was a notable side effect, reported by 30% of patients at 2 months and 42.8% at 4 months. Despite the study's limitations, SD in low alternating doses appeared effective, but further controlled studies were recommended to confirm these findings.
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