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GlossaryEpigenome

chemical modifications to DNA and histones regulating gene expression

The epigenome consists of chemical modifications to DNA and histone proteins that regulate gene expression without altering the underlying DNA sequence. These modifications can be influenced by environmental factors and can affect how genes are turned on or off, playing a crucial role in development, disease, and even conditions like alopecia.

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research The Agouti Mouse Model: An Epigenetic Biosensor for Nutritional and Environmental Alterations on the Fetal Epigenome

231 citations , July 2008 in “Nutrition reviews”

Diet changes can protect against harmful environmental effects on fetal development.

research Toward Elucidating Epigenetic and Metabolic Regulation of Stem Cell Lineage Plasticity in Skin Aging

7 citations , May 2022 in “Frontiers in Cell and Developmental Biology”

Epigenetic and metabolic changes affect stem cell function and aging in skin.

research Study of the Role of Genetic and Epigenetic Variability in Facial Skin and Scalp Hair Aging and Genetic Prediction of Age-Related Human Appearance Traits

March 2024 in “Jagiellonian University Repository (Jagiellonian University)”

Genetic and lifestyle factors influence skin and hair aging, and prediction models can help assess aging and cosmetic treatments.

research Maternal Iron Status in Early Pregnancy and DNA Methylation in Offspring: An Epigenome-Wide Meta-Analysis

May 2022 in “Clinical Epigenetics”

A mother's iron levels early in pregnancy can influence the DNA makeup of her child, potentially affecting the child's health.

research Charting the Bromodomain BRD4: Towards the Identification of Novel Inhibitors with Molecular Similarity and Receptor Mapping

10 citations , November 2017 in “Letters in drug design & discovery”

Researchers identified promising inhibitors for the BRD4 protein, including finasteride and amentoflavone.

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community Journey against alopecia - Finasteride 3 month

in Progress Pictures 16 upvotes 4 years ago

A 26-year-old man from France started experiencing hair loss in September 2020 and began using finasteride in June 2021, reporting some improvement after three months without side effects. He plans to continue finasteride for a year before considering additional treatments like minoxidil or dermarolling.

community Genetics are so weird and unpredictable

in Minoxidil 118 upvotes 1 year ago

The user experienced male pattern baldness starting at 18, tried finasteride with no success, and switched to dutasteride, which halted hair loss. Minoxidil had no effect for them, while their brother, who didn't use AR inhibitors, maintained a juvenile hairline and successfully grew a beard with minoxidil, highlighting the unpredictable nature of genetics in hair loss and treatment response.

community Why is it barely impossible to find balding South Korean men

in Research/Science 251 upvotes 2 years ago

The post discusses the rarity of baldness among South Korean men. Users suggest this could be due to early treatment, high beauty standards, accessibility of healthcare, and genetics. Treatments like finasteride and dutasteride are commonly used, and hair transplants are also popular.