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GlossaryEpigenome

chemical modifications to DNA and histones regulating gene expression

The epigenome consists of chemical modifications to DNA and histone proteins that regulate gene expression without altering the underlying DNA sequence. These modifications can be influenced by environmental factors and can affect how genes are turned on or off, playing a crucial role in development, disease, and even conditions like alopecia.

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research The Agouti Mouse Model: An Epigenetic Biosensor for Nutritional and Environmental Alterations on the Fetal Epigenome

231 citations, July 2008 in “Nutrition reviews”

Diet changes can protect against harmful environmental effects on fetal development.

research Maternal Iron Status in Early Pregnancy and DNA Methylation in Offspring: An Epigenome-Wide Meta-Analysis

May 2022 in “Clinical Epigenetics”

A mother's iron levels early in pregnancy can influence the DNA makeup of her child, potentially affecting the child's health.

research Tissue Mechanics in Haired Murine Skin: Potential Implications for Skin Aging

9 citations, February 2021 in “Frontiers in Cell and Developmental Biology”

Older mice have stiffer skin with less elasticity due to changes in collagen and skin structure, affecting aging and hair loss.

research Dynamics and Epigenetics of the Epidermal Differentiation Complex

February 2024 in “Epigenomes”

Epigenetic mechanisms control skin development by regulating gene expression.

research The Role of Histone Demethylases in Disease

1 citations, January 2011 in “Springer eBooks”

Histone demethylases play a key role in the development of many diseases and may be targets for treatment.

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community Genetics are so weird and unpredictable

in Minoxidil 118 upvotes 1 month ago

The user experienced male pattern baldness starting at 18, tried finasteride with no success, and switched to dutasteride, which halted hair loss. Minoxidil had no effect for them, while their brother, who didn't use AR inhibitors, maintained a juvenile hairline and successfully grew a beard with minoxidil, highlighting the unpredictable nature of genetics in hair loss and treatment response.

community Why is it barely impossible to find balding South Korean men

in Research/Science 246 upvotes 1 year ago

The post discusses the rarity of baldness among South Korean men. Users suggest this could be due to early treatment, high beauty standards, accessibility of healthcare, and genetics. Treatments like finasteride and dutasteride are commonly used, and hair transplants are also popular.