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    Glossary Epigenome

    chemical modifications to DNA and histones regulating gene expression

    The epigenome consists of chemical modifications to DNA and histone proteins that regulate gene expression without altering the underlying DNA sequence. These modifications can be influenced by environmental factors and can affect how genes are turned on or off, playing a crucial role in development, disease, and even conditions like alopecia.

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    1. The agouti mouse model: an epigenetic biosensor for nutritional and environmental alterations on the fetal epigenome Nutrition reviews · 2008 · 231 citations
    2. The Transcriptomics and Epigenomics of Hair Follicles Updates in clinical dermatology · 2024
    3. Identifying molecular targets for reverse aging using integrated network analysis of transcriptomic and epigenomic changes during aging Scientific Reports · 2021 · 12 citations
    4. Maternal iron status in early pregnancy and DNA methylation in offspring: an epigenome-wide meta-analysis Clinical Epigenetics · 2022
    5. Toward Elucidating Epigenetic and Metabolic Regulation of Stem Cell Lineage Plasticity in Skin Aging Frontiers in Cell and Developmental Biology · 2022 · 7 citations
    6. Badanie roli zmienności genetycznej i epigenetycznej w starzeniu się skóry twarzy i włosów głowy oraz genetyczna predykcja związanych z wiekiem cech wyglądu człowieka Jagiellonian University Repository (Jagiellonian University) · 2024
    7. A State-of-the-Art Overview on (Epi)Genomics and Personalized Skin Rejuvenating Strategies Pharmaceutics · 2025
    8. Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition Cell stem cell · 2016 · 174 citations
    9. Identifying critical cell types and gene regulatory pathways for hair and skin disease Nature Genetics · 2023
    10. All Roads Go to the Nucleus: Integration of Signaling/Transcription Factor-Mediated and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration Stem cell biology and regenerative medicine · 2018
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