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GlossaryHairless Gene

gene regulating hair growth, mutations cause permanent hair loss

The Hairless Gene, often abbreviated as HR gene, is a gene that plays a crucial role in the regulation of hair growth and development. Mutations in this gene can lead to conditions such as congenital atrichia, where individuals are born with hair that is subsequently lost and not regrown, resulting in permanent hairlessness. This gene is essential for the normal cycling of hair follicles and the maintenance of hair.

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research Atrichia Caused by Mutations in the Vitamin D Receptor Gene Is a Phenocopy of Generalized Atrichia Caused by Mutations in the Hairless Gene

139 citations, September 2001 in “The journal of investigative dermatology/Journal of investigative dermatology”

Mutations in the Vitamin D receptor gene can cause hair loss similar to mutations in the Hairless gene.

research A Distinct Gene Close to the Hairless Locus on Chromosome 8p Underlies Hereditary Marie Unna Type Hypotrichosis in a German Family

36 citations, October 2000 in “British Journal of Dermatology”

A different gene near the hairless gene on chromosome 8p21 causes a rare hair loss condition in a German family.

research Intragenic Deletion in the Desmoglein 4 Gene Underlies the Skin Phenotype in the Iffa Credo Hairless Rat

28 citations, October 2004 in “Differentiation”

A gene deletion causes the "hairless" trait in Iffa Credo rats.

research Atrichia With Papular Lesions Resulting From a Novel Insertion Mutation in the Human Hairless Gene

19 citations, May 2006 in “Clinical and Experimental Dermatology”

Researchers found a new mutation causing total hair loss from birth.

research Hairless Plays a Role in Formation of Inner Root Sheath via Regulation of Dlx3 Gene

17 citations, May 2012 in “Journal of biological chemistry/The Journal of biological chemistry”

Hairless protein affects hair follicle structure by regulating the Dlx3 gene.

Taking Advantage of Phenotype Variability in a Local Animal Genetic Resource: Identification of Genomic Regions Associated with the Hairless Phenotype in Casertana Pigs

research Taking Advantage of Phenotype Variability in a Local Animal Genetic Resource: Identification of Genomic Regions Associated with the Hairless Phenotype in Casertana Pigs

16 citations, April 2018 in “Animal Genetics”

Researchers found two genes that may explain why some Casertana pigs don't have hair.

research The Hairless Gene in Androgenetic Alopecia: Results of a Systematic Mutation Screening and a Family-Based Association Approach

15 citations, April 2002 in “British Journal of Dermatology”

Hairless gene not strongly linked to baldness.

research Variant 1859G→A (Arg620Gln) of the Hairless Gene: Absence of Association with Papular Atrichia or Androgenetic Alopecia

14 citations, July 2001 in “American Journal of Human Genetics”

Haplogroup X found in Altaian population supports Amerindian origin.

research Molecular Basis for Hair Loss in Mice Carrying a Novel Nonsense Mutation (Hr^rh-R) in the Hairless Gene (Hr)

10 citations, January 2010 in “Veterinary pathology”

A new mutation in the hairless gene causes hair loss and skin wrinkling in mice.

research Androgenetic Alopecia in Heterozygous Carriers of a Mutation in the Human Hairless Gene

9 citations, June 2000 in “Journal of The American Academy of Dermatology”

Mutation in hairless gene may increase hair loss risk.

research Disease Causing Homozygous Variants in the Human Hairless Gene

7 citations, December 2015 in “International Journal of Dermatology”

New and known mutations in the hairless gene cause a hair loss condition called Atrichia with papular lesions.

research Hairless-Knockout Piglets Generated Using CRISPR/Cas9 Exhibit Abnormalities in Skin and Thymus

3 citations, January 2019 in “Jikken doubutsu ihou/Jikken doubutsu/Experimental animals/Jikken Dobutsu”

Pigs without the Hairless gene showed skin and thymus changes, useful for studying human hair disorders.

research Hypomorphic Mutation in the Hairless Gene Accelerates Pruritic Atopic Skin Caused by Feeding a Special Diet to Mice

3 citations, March 2016 in “Experimental Dermatology”

A mutation in the hairless gene speeds up severe itchy skin in mice on a special diet.

research Atrichia with Papular Lesions in a Taiwanese Patient Without Hairless (HR) Gene Mutation

3 citations, March 2010 in “Dermatologica Sinica”

A Taiwanese patient had hair loss and skin bumps without the usual gene mutation, suggesting other genetic factors might be involved.

research Androgenetic Alopecia in Heterozygous Carriers of a Mutation in the Human Hairless Gene

2 citations, June 2000 in “Journal of The American Academy of Dermatology”

Mutation in hairless gene may increase hair loss risk.

research Relationship of a Novel c.429delC Deletion in Hairless Gene HR with Alopecia in Two Families from Southern Punjab, Pakistan

August 2020 in “Pakistan Journal of Zoology”

A new mutation in the Hairless gene causes hair loss in two Pakistani families.

research Hairless Down-Regulates Expression of Msx2 and Its Related Target Genes in Hair Follicles

14 citations, April 2013 in “Journal of dermatological science”

Hairless protein reduces Msx2 gene activity, affecting hair follicle development.

research Vitamin D Receptor-Mediated Control of Soggy, Wise, and Hairless Gene Expression in Keratinocytes

13 citations, November 2013 in “Journal of Endocrinology/Journal of endocrinology”

Vitamin D receptor helps control hair growth genes in skin cells.

research ‘Atrichosis’, a new hairless gene with cyst formation in rats

5 citations, February 1981 in “Experientia”

Loss-Of-Function Mutations of an Inhibitory Upstream ORF in the Human Hairless Transcript Cause Marie Unna Hereditary Hypotrichosis

research Loss-Of-Function Mutations of an Inhibitory Upstream ORF in the Human Hairless Transcript Cause Marie Unna Hereditary Hypotrichosis

181 citations, January 2009 in “Nature Genetics”

Certain mutations in a hair growth-related gene cause a type of genetic hair loss.

research The Hairless Gene of the Mouse: Relationship of Phenotypic Effects with Expression Profile and Genotype

52 citations, October 1999 in “Developmental Dynamics”

Mutations in the hairless gene in mice affect its expression and lead to a range of developmental issues in multiple tissues.

research Characterization of Hairless (Hr) and FGF5 Genes Provides Insights into the Molecular Basis of Hair Loss in Cetaceans

50 citations, February 2013 in “BMC evolutionary biology”

Cetaceans lost hair due to changes in the Hr and FGF5 genes.

research Interactions of the Vitamin D Receptor with the Corepressor Hairless

42 citations, July 2007 in “Journal of Biological Chemistry”

Most Hairless gene mutations reduce its ability to work with the Vitamin D Receptor, which might explain a certain type of hair loss.

research Marie Unna Hereditary Hypotrichosis Caused by a Novel Mutation in the Human Hairless Transcript

14 citations, July 2010 in “Experimental Dermatology”

A new mutation in the HR gene causes hair loss in a specific family.

research Ligand-Independent Regulation of the Hairless Promoter by Vitamin D Receptor

10 citations, February 2008 in “Photochemistry and photobiology”

Vitamin D receptor can control the hairless gene linked to hair loss even without vitamin D.

research The Near-Naked Hairless Mutation Disrupts Hair Formation but Is Not Due to a Mutation in the Hairless Coding Region

8 citations, March 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

The near-naked hairless mutation causes hair loss but is not due to a mutation in the hairless gene itself.

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Related Terms

Research

research Atrichia Caused by Mutations in the Vitamin D Receptor Gene Is a Phenocopy of Generalized Atrichia Caused by Mutations in the Hairless Gene

research A Distinct Gene Close to the Hairless Locus on Chromosome 8p Underlies Hereditary Marie Unna Type Hypotrichosis in a German Family

research Intragenic Deletion in the Desmoglein 4 Gene Underlies the Skin Phenotype in the Iffa Credo Hairless Rat

research Atrichia With Papular Lesions Resulting From a Novel Insertion Mutation in the Human Hairless Gene

research Hairless Plays a Role in Formation of Inner Root Sheath via Regulation of Dlx3 Gene

research Taking Advantage of Phenotype Variability in a Local Animal Genetic Resource: Identification of Genomic Regions Associated with the Hairless Phenotype in Casertana Pigs

research The Hairless Gene in Androgenetic Alopecia: Results of a Systematic Mutation Screening and a Family-Based Association Approach

research Variant 1859G→A (Arg620Gln) of the Hairless Gene: Absence of Association with Papular Atrichia or Androgenetic Alopecia

research Molecular Basis for Hair Loss in Mice Carrying a Novel Nonsense Mutation (Hr^rh-R) in the Hairless Gene (Hr)

research Androgenetic Alopecia in Heterozygous Carriers of a Mutation in the Human Hairless Gene

research Disease Causing Homozygous Variants in the Human Hairless Gene

research Hairless-Knockout Piglets Generated Using CRISPR/Cas9 Exhibit Abnormalities in Skin and Thymus

research Hypomorphic Mutation in the Hairless Gene Accelerates Pruritic Atopic Skin Caused by Feeding a Special Diet to Mice

research Atrichia with Papular Lesions in a Taiwanese Patient Without Hairless (HR) Gene Mutation

research Androgenetic Alopecia in Heterozygous Carriers of a Mutation in the Human Hairless Gene

research Relationship of a Novel c.429delC Deletion in Hairless Gene HR with Alopecia in Two Families from Southern Punjab, Pakistan

research Hairless Down-Regulates Expression of Msx2 and Its Related Target Genes in Hair Follicles

research Vitamin D Receptor-Mediated Control of Soggy, Wise, and Hairless Gene Expression in Keratinocytes

research ‘Atrichosis’, a new hairless gene with cyst formation in rats

research Loss-Of-Function Mutations of an Inhibitory Upstream ORF in the Human Hairless Transcript Cause Marie Unna Hereditary Hypotrichosis

research The Hairless Gene of the Mouse: Relationship of Phenotypic Effects with Expression Profile and Genotype

research Characterization of Hairless (Hr) and FGF5 Genes Provides Insights into the Molecular Basis of Hair Loss in Cetaceans

research Interactions of the Vitamin D Receptor with the Corepressor Hairless

research Marie Unna Hereditary Hypotrichosis Caused by a Novel Mutation in the Human Hairless Transcript

research Ligand-Independent Regulation of the Hairless Promoter by Vitamin D Receptor

research The Near-Naked Hairless Mutation Disrupts Hair Formation but Is Not Due to a Mutation in the Hairless Coding Region

research Hairless Controls Hair Fate Decision via Wnt/β-Catenin Signaling

research Atrichia With Papular Lesions Confirmed Via Genetic Testing: A Case Report

research Functional Mapping of the Mouse Hairless Gene Promoter Region

research Hairless: A Nuclear Receptor Corepressor Essential for Skin Function