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    Glossary Hairless Gene

    gene regulating hair growth, mutations cause permanent hair loss

    The Hairless Gene, often abbreviated as HR gene, is a gene that plays a crucial role in the regulation of hair growth and development. Mutations in this gene can lead to conditions such as congenital atrichia, where individuals are born with hair that is subsequently lost and not regrown, resulting in permanent hairlessness. This gene is essential for the normal cycling of hair follicles and the maintenance of hair.

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    1. The <i>hairless</i> gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor Genes & Development · 2001 · 178 citations
    2. The Role of the Hairless (hr) Gene in the. Regulation of Hair Follicle Catagen Transformation American Journal Of Pathology · 1999 · 166 citations
    3. Atrichia Caused by Mutations in the Vitamin D Receptor Gene is a Phenocopy of Generalized Atrichia Caused by Mutations in the Hairless Gene 2001 · 139 citations
    4. Molecular and functional aspects of the hairless (<i>hr</i>) gene in laboratory rodents and humans Experimental Dermatology · 1998 · 126 citations
    5. A Missense Mutation in the Zinc-Finger Domain of the Human Hairless Gene Underlies Congenital Atrichia in a Family of Irish Travellers The American Journal of Human Genetics · 1998 · 83 citations
    6. A novel missense mutation (C622G) in the zinc‐finger domain of the human hairless gene associated with congenital atrichia with papular lesions Experimental Dermatology · 2000 · 47 citations
    7. A Homozygous Nonsense Mutation in the Zinc-Finger Domain of the Human Hairless Gene Underlies Congenital Atrichia Journal of Investigative Dermatology · 1999 · 37 citations
    8. A distinct gene close to the hairless locus on chromosome 8p underlies hereditary Marie Unna type hypotrichosis in a German family British Journal of Dermatology · 2000 · 36 citations
    9. Compound Heterozygous Mutations in the Hairless Gene in Atrichia with Papular Lesions Journal of Investigative Dermatology · 2003 · 23 citations
    10. Atrichia with papular lesions resulting from a novel homozygous missense mutation in the hairless gene Clinical and Experimental Dermatology · 2003 · 20 citations
    11. Atrichia with papular lesions resulting from a novel insertion mutation in the human hairless gene Clinical and Experimental Dermatology · 2006 · 19 citations
    12. A novel missense mutation in the mouse hairless gene causes irreversible hair loss: Genetic and molecular analyses of Hrm1Enu Genomics · 2006 · 18 citations
    13. Hairless Plays a Role in Formation of Inner Root Sheath via Regulation of Dlx3 Gene 2012 · 17 citations
    14. Taking advantage from phenotype variability in a local animal genetic resource: identification of genomic regions associated with the hairless phenotype in Casertana pigs Animal Genetics · 2018 · 16 citations
    15. The hairless gene in androgenetic alopecia: results of a systematic mutation screening and a family-based association approach British Journal of Dermatology · 2002 · 15 citations
    16. Variant 1859G→A (Arg620Gln) of the “Hairless” Gene: Absence of Association with Papular Atrichia or Androgenetic Alopecia American Journal of Human Genetics · 2001 · 14 citations
    17. Congenital atrichia with papular lesions resulting from novel mutations in human hairless gene in four consanguineous families The Journal of Dermatology · 2011 · 11 citations
    18. Molecular Basis for Hair Loss in Mice Carrying a Novel Nonsense Mutation (<i>Hr<sup>rh-R</sup></i>) in the Hairless Gene (<i>Hr</i>) Veterinary pathology · 2010 · 10 citations
    19. Androgenetic alopecia in heterozygous carriers of a mutation in the human hairless gene Journal of The American Academy of Dermatology · 2000 · 9 citations
    20. Disease causing homozygous variants in the human hairless gene International Journal of Dermatology · 2015 · 7 citations
    21. ‘Atrichosis’, a new hairless gene with cyst formation in rats Experientia · 1981 · 5 citations
    22. Marie Unna Hereditary Hypotrichosis Gene Maps to Human Chromosome 8p21 Near Hairless Journal of Investigative Dermatology · 2000 · 4 citations
    23. Hairless-knockout piglets generated using the clustered regularly interspaced short palindromic repeat/CRISPR-associated-9 exhibit abnormalities in the skin and thymus 2019 · 3 citations
    24. Hypomorphic mutation in the hairless gene accelerates pruritic atopic skin caused by feeding a special diet to mice Experimental Dermatology · 2016 · 3 citations
    25. Atrichia with papular lesions in a Taiwanese patient without hairless (HR) gene mutation Dermatologica Sinica · 2010 · 3 citations
    26. Androgenetic alopecia in heterozygous carriers of a mutation in the human hairless gene Journal of The American Academy of Dermatology · 2000 · 2 citations
    27. Relationship of a Novel c.429delC Deletion in Hairless Gene HR with Alopecia in Two Families from Southern Punjab, Pakistan Pakistan Journal of Zoology · 2020
    28. Analyse de la régulation du gène Hairless et identification des voies de signalisation affectées chez les mutants «bald Mill Hill». HAL (Le Centre pour la Communication Scientifique Directe) · 2008
    29. [Molecular cloning of full-long cDNA sequences encoding hairless gene in the Kunming mouse]. PubMed · 2005
    30. The Effect of Hairless Mutant Gene on The Thymus and Skin Under The C_(57)BL/6 Genetic Background Laboratory Animal Science and Administration · 2004