The Stumptailed Macaque as a Model for Baldness: Effects of Minoxidil

April 1986 in “ International Journal of Cosmetic Science ”

Hideo Uno

minoxidil male pattern baldness terminal hairs topical application epidermal keratinocytes sebaceous glands dermal components Rogaine

TLDR Minoxidil promotes hair regrowth in early baldness stages and prevents baldness in non-bald scalps.

The study investigated the effects of minoxidil on baldness in stumptailed macaques, which is biologically similar to male pattern baldness in humans. The researchers found that topical application of minoxidil induced regrowth of terminal hairs in bald scalps of macaques, with greater results in the early stages of baldness in adolescent and young adults. Minoxidil also prevented the development of baldness when applied on non-bald scalps of peri-adolescent animals. The study concluded that the stumptailed macaque is a useful animal model for the study of human male pattern baldness, and minoxidil has no influence on epidermal keratinocytes, sebaceous glands, and other dermal components.

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Research cited in this study

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research Cyclic Dynamics of Hair Follicles and the Effect of Minoxidil on the Bald Scalps of Stumptailed Macaques

54 citations, June 1985 in “American Journal of Dermatopathology”

Minoxidil helps grow longer, thicker hair in bald scalps of stumptailed macaques, and early treatment is more effective.

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in Progress Pictures 324 upvotes 2 years ago

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research The Effect of Topical RU58841 (Androgen Receptor Blocker) Combined with Minoxidil on Hair Growth in Macaque Androgenetic Alopecia

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Combining RU58841 and minoxidil significantly increases hair growth.