A Multifunctional Cholesterol-Free Liposomal Platform Based on Protopanaxadiol for Alopecia Therapy

July 2022 in “ Nano Research ”

Xuefei Zhang, Shuxuan Li, Yating Dong, Hehui Rong, Junke Zhao, Haiyan Hu

protopanaxadiol PPD liposomal platform alopecia therapy testosterone biosynthesis hair follicles dermal papilla cells angiogenesis telogen alopecia androgenetic alopecia dutasteride anti-alopecia agents hair growth hair regrowth hair loss treatment

TLDR A cholesterol-free liposomal platform using protopanaxadiol effectively promotes hair growth and treats alopecia.

The study developed a cholesterol-free liposomal platform using protopanaxadiol (PPD) to enhance alopecia therapy by avoiding testosterone biosynthesis, which could harm hair follicles. PPD-Lip not only served as a drug delivery system but also actively promoted hair growth by enhancing dermal papilla cell activity and angiogenesis. It demonstrated effectiveness in promoting hair regrowth in both telogen and androgenetic alopecia mouse models. Additionally, PPD-Lip loaded with dutasteride showed increased efficacy in treating androgenetic alopecia, suggesting its potential as a versatile platform for delivering various anti-alopecia agents.

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