Cyclical Dermal Micro-Niche Switching Governs the Morphological Infradian Rhythm of Mouse Zigzag Hair

    August 2023 in “ Nature Communications ”
    Makoto Takeo, Koh‐éi Toyoshima, Riho Fujimoto … Takashi Tsuji
    Studysummary In this study, researchers observed that the combination of hair progenitors and their micro-niche changes every three days in mouse zigzag hair, and disruptions in specific genes affected this rhythm, highlighting the importance of this periodic change for normal hair morphology.
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    Research cited in this study 9

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    2. Epithelial-Mesenchymal Micro-Niches Govern Stem Cell Lineage Choices Cell · 2017
    3. Local Circadian Clock Gates Cell Cycle Progression of Transient Amplifying Cells During Regenerative Hair Cycling Proceedings of the National Academy of Sciences of the United States of America · 2013
    4. Fully Functional Hair Follicle Regeneration Through the Rearrangement of Stem Cells and Their Niches Nature Communications · 2012
    5. Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration Cell · 2011
    6. The Basement Membrane Of Hair Follicle Stem Cells Is A Muscle Cell Niche Cell · 2011
    7. Changes in Structure and Geometric Properties of Human Hair by Aging International Journal of Cosmetic Science · 2010
    8. Epidermal Patterning and Induction of Different Hair Types During Mouse Embryonic Development Birth defects research · 2009
    9. Overexpression Of Sonic Hedgehog Suppresses Embryonic Hair Follicle Morphogenesis Developmental Biology · 2003