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research Gain-Of-Function Variants In The ODC1 Gene Cause A Syndromic Neurodevelopmental Disorder Associated With Macrocephaly, Alopecia, Dysmorphic Features, And Neuroimaging Abnormalities

28 citations, November 2018 in “American Journal of Medical Genetics Part A”

ODC1 gene mutations cause a neurodevelopmental disorder with large head size, hair loss, and facial abnormalities.

research Hair Loss Caused by Gain-of-Function Mutant TRPV3 Is Associated with Premature Differentiation of Follicular Keratinocytes

11 citations, August 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

A gene mutation causes early keratinocyte maturation leading to hair loss in Olmsted syndrome.

research TRPV3 Gain-of-Function Mutation Impairs Differentiation of Hair Follicle Inner Root Sheath

April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

A specific mutation in the TRPV3 gene causes hair follicle cells to develop improperly, leading to hair loss.

research Prediction of Gain-of-Function and Loss-of-Function Mutations Using Combined Annotation Dependent Depletion

1 citations, September 2017

C-scores can help predict gain-of-function and loss-of-function mutations.

research Biological Significance of FoxN1 Gain-of-Function Mutations During T and B Lymphopoiesis in Juvenile Mice

16 citations, October 2014 in “Cell death and disease”

FoxN1 overexpression in young mice harms immune cell and skin development.

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community Got a microscope camera. Here’s the difference between healthy and miniaturized hair

in Progress Pictures 492 upvotes 3 years ago

A user who shared progress pictures of their scalp using a microscope camera, demonstrating the difference between healthy and miniaturized hair. Various explanations for the cause of this were discussed, such as DHT build-up in scalp sebum causing an autoimmune response leading to inflammation and eventual hair loss, with some suggesting a do-it-yourself treatment involving adding ascorbic acid powder to shampoo.

community Sublingual Minoxidil - Cure to Hairloss?

in Minoxidil 583 upvotes 1 year ago

The conversation discusses the potential benefits of sublingual minoxidil for hair loss treatment. It suggests that sublingual minoxidil, which bypasses the liver, may have fewer side effects, greater bioavailability, and could be more effective than oral minoxidil.

community 9 months of finasteride - progress??

in Progress Pictures 214 upvotes 1 month ago

The user shared progress pictures after 9 months of using oral finasteride and topical minoxidil for hair loss, noting improvements in hair density. Concerns about side effects of finasteride were discussed, with some users sharing personal experiences.

community 29M, 5.5 months of: 0.5mg finasteride, 5% minoxidil, 1.5mm microneedling once a week and 20mg RU58841. No notable sides. I feel much better, and happy to have started treatment just in time. I just wish I started sooner! The dandruffy gunk you see is definitely propylene glycol from minoxidil :')

in Progress Pictures 565 upvotes 3 years ago

User shared 5.5-month progress using 0.5mg finasteride, 5% minoxidil, 1.5mm microneedling weekly, and 20mg RU58841, with positive results and no side effects. Others discussed their experiences, dosage adjustments, and the importance of age in treatment efficacy.

community Fats on your Head to Stop Hair Loss?

in Research/Science 140 upvotes 1 year ago

The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

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