July 2025 in “The FASEB Journal” This study reported that exosomes derived from human amniotic mesenchymal stem cells (hAMSC-exo) accelerated hair growth in androgenetic alopecia mice by enhancing signals between hair follicle cells and improving cellular environments, particularly protecting against dihydrotestosterone-induced damage via Wnt/β-catenin signaling.
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June 2021 in “Frontiers in Cell and Developmental Biology” This study suggests that exosomal miRNAs from human amniotic fluid stem cells may inhibit myofibroblast differentiation and reduce fibrotic scarring in wound healing.
March 2025 in “World Journal of Stem Cells” This study found that human adipose-derived MSC exosomes (hADSC-Exos) may enhance dermal papillary cell proliferation and migration by activating the Wnt/β-catenin signaling pathway, potentially reversing the effects of dihydrotestosterone in androgenetic alopecia.
April 2026 in “Biomaterials and Biosystems” This study found that combining multiple low-dose exosome injections with NIR-II-responsive selenium telluride-mediated photothermal therapy significantly improved healing in diabetic mice with pressure ulcers, enhancing wound closure, hair follicle regeneration, and collagen remodeling compared to single high-dose exosome treatment.
May 2025 in “World Journal of Stem Cells” This study discusses the potential of exosomes from human adipose-derived mesenchymal stem cells in enhancing dermal papilla cell proliferation via the Wnt/β-catenin pathway, suggesting a novel treatment approach for androgenetic alopecia by counteracting excessive dihydrotestosterone effects.