Potential of Mesenchymal Stem Cell-Derived Exosomes in the Treatment of Androgenetic Alopecia

The study explores the potential of exosomes derived from human adipose-derived mesenchymal stem cells (hADSC-Exos) in treating androgenetic alopecia. These exosomes enhance dermal papilla cell proliferation through the Wnt/β-catenin pathway, counteracting the effects of dihydrotestosterone. The research demonstrates that hADSC-Exos can significantly promote hair follicle regeneration, showing comparable efficacy to minoxidil in an androgenetic alopecia mouse model. The study highlights the promise of exosome-based therapies as a cell-free approach for hair restoration, though challenges such as scalability, standardization, and regulatory approval remain before clinical implementation. Future research should focus on optimizing production, exploring signaling pathways, and conducting large-scale trials to validate efficacy and safety.