Adipose-Derived Cellular and Cell-Derived Regenerative Therapies in Dermatology and Aesthetic Rejuvenation

The 2019 document reviews the use of adipose-derived products for dermatologic and aesthetic applications, including hair growth and scar improvement. It covers the historical background of fat grafting, adipose collection techniques, and regulatory guidelines. The review highlights the potential of adipose-derived components like nanofat, SVF, ASCs, and EVs for tissue repair and rejuvenation, and their characterization by specific markers. Studies cited within the document demonstrate the effectiveness of these therapies in increasing hair density and diameter, with one study showing a mean increase of 31 hairs/cm² using SVF-enhanced autologous fat grafts. For scar reduction, products like nanofat and ASC-CM have shown improvements in appearance and pliability. The document also discusses the use of these therapies for skin ischemia-reperfusion injury and facial rejuvenation, with studies indicating benefits in wound healing and skin repair. However, it calls for more rigorous trials to provide stronger medical evidence and to understand the mechanisms behind these therapies. The document also notes the challenges in the field, such as the lack of standardized nomenclature and assessment methods, and emphasizes the need for further extensive clinical trials.