TLDR The same hormone can affect gene expression differently in various tissues, which could lead to new treatments for conditions like hair loss.
The 2012 study "Tissue-Selective Regulation of Androgen-Responsive Genes" investigated how androgens, specifically Dihydrotestosterone (DHT), regulate different sets of genes in various tissues. The researchers found that the same hormone can have different effects on gene expression depending on the tissue it is acting upon, suggesting a high degree of tissue-selective regulation. This discovery has significant implications for understanding the role of androgens in various physiological processes, including hair growth and hair loss. The study also suggested that this tissue-selective regulation could be exploited for therapeutic purposes, potentially leading to new treatments for conditions like alopecia and other androgen dependent disorders.
11 citations,
August 2009 in “Expert Opinion on Drug Discovery” We need better ways to test and understand SARMs to make safer and more effective treatments.
52 citations,
June 2009 in “Current Opinion in Endocrinology, Diabetes and Obesity” The document concludes that hair transplantation and gene therapy may be important for future hair loss treatment.
13 citations,
June 2007 in “Journal of Dermatological Science” Researchers created a cell line to study hair growth and found specific genes affected by dihydrotestosterone.
229 citations,
August 2002 in “Experimental Gerontology” AGA causes hair loss by shrinking hair follicles due to DHT binding, and can be treated with finasteride and minoxidil.
9 citations,
January 1997 in “Gynecological Endocrinology” The document concludes that treating androgen excess needs patience, managing expectations is important, and many drugs used are not officially approved, suggesting cosmetic options for mild cases.
11 citations,
August 2009 in “Expert Opinion on Drug Discovery” We need better ways to test and understand SARMs to make safer and more effective treatments.
56 citations,
January 2015 in “Circulation” Finasteride helps reduce heart issues and improves heart function.
16 citations,
September 2018 in “Journal of Ethnopharmacology” Plant-based remedies may treat hair loss by reducing inflammation and improving insulin resistance.
89 citations,
August 2013 in “PloS one” Androgen receptors are active in many tissues of both male and female mice, not just reproductive organs.
22 citations,
November 2011 in “Journal of Analytical Toxicology” Scientists have developed a new method to detect steroid abuse in athletes using cell-based tests, which could be the future of anti-doping methods.
