Tissue-Selective Regulation of Androgen-Responsive Genes

May 2012 in “ Endocrine Research ”

Maya Otto-Duessel, Miaoling He, Jeremy O. Jones

androgens Dihydrotestosterone DHT gene expression tissue-selective regulation hair growth hair loss alopecia androgen dependent disorders

TLDR The same hormone can affect gene expression differently in various tissues, which could lead to new treatments for conditions like hair loss.

The 2012 study "Tissue-Selective Regulation of Androgen-Responsive Genes" investigated how androgens, specifically Dihydrotestosterone (DHT), regulate different sets of genes in various tissues. The researchers found that the same hormone can have different effects on gene expression depending on the tissue it is acting upon, suggesting a high degree of tissue-selective regulation. This discovery has significant implications for understanding the role of androgens in various physiological processes, including hair growth and hair loss. The study also suggested that this tissue-selective regulation could be exploited for therapeutic purposes, potentially leading to new treatments for conditions like alopecia and other androgen dependent disorders.

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