Improving Selective Androgen Receptor Modulator Discovery and Preclinical Evaluation

    August 2009 in “ Expert Opinion on Drug Discovery ”
    Jeremy O. Jones
    Studysummary This review discusses current challenges in selective androgen receptor modulator discovery and preclinical evaluation and reports no new results, emphasizing the need for basic research to improve safety and selectivity.
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    Research cited in this study 7

    1. Androgens and Hair Loss: An In-Depth Analysis of Androgenetic Alopecia Current Opinion in Endocrinology, Diabetes and Obesity · 2009
    2. Pharmacology of Anabolic Steroids British Journal of Pharmacology · 2008
    3. (1R,2S)-4-(2-Cyano-Cyclohexyl-Oxy)-2-Trifluoromethyl-Benzonitrile, A Potent Androgen Receptor Antagonist For Stimulating Hair Growth And Reducing Sebum Production Bioorganic & Medicinal Chemistry Letters · 2007
    4. Molecular Basis of Androgen Insensitivity Molecular and Cellular Endocrinology · 2001
    5. Gender Differences in the Regulation of Blood Pressure Hypertension · 2001
    6. Treatment of Androgen Excess in Females: Yesterday, Today, and Tomorrow Gynecological Endocrinology · 1997
    7. Androgen Antagonists in Androgen Target Tissues Pharmacology & Therapeutics · 1984