TLDR Different substances that activate or block the androgen receptor can affect male development and treat conditions like prostate cancer.
The document from 2018 examines the role of the androgen receptor (AR) in the body, which is activated by hormones such as testosterone and dihydrotestosterone (DHT). These hormones lead to changes in the AR that affect gene regulation. AR agonists, including natural hormones and synthetic compounds like mesterolone and selective androgen receptor modulators (SARMs), play a key role in male development, reproductive health, and other bodily functions. The document also discusses the concept of intracrinology, particularly in the prostate and its relevance to prostate cancer. It compares the binding affinities of various synthetic AR agonists to DHT. Additionally, AR antagonists are highlighted for their therapeutic potential in treating conditions like prostate cancer, acne, and androgenic alopecia, noting the difference between steroidal and non-steroidal inhibitors.
12 citations,
March 2017 in “Arteriosclerosis, thrombosis, and vascular biology” Testosterone helps prevent skin damage in males by acting through both estrogen and androgen pathways.
153 citations,
March 2017 in “Endocrine” Male pattern baldness involves genetics, hormones, and needs better treatments.
25 citations,
June 2014 in “Journal of Endocrinology/Journal of endocrinology” Human sebaceous glands contain enzymes that affect androgen production and may influence sebum production and acne.
77 citations,
May 2012 in “Expert Opinion on Emerging Drugs” New treatments for male hypogonadism are effective and should be personalized.
6 citations,
April 2017 in “Frontiers in Pharmacology” Chinese medicine may help treat hair loss by affecting genes and enzyme activity.
37 citations,
November 1995 in “Journal of Investigative Dermatology” Topical finasteride and flutamide reduce gland size and enzyme activity, with flutamide being more potent, potentially treating acne, seborrhea, hirsutism, and androgenic alopecia.
12 citations,
September 2017 in “Molecular and Cellular Endocrinology” Testosterone significantly affects sexual desire in both men and women, but its impact on women is more complex and influenced by psychological factors.
October 2023 in “Frontiers in endocrinology” Androgens and androgen receptors are important for metabolic health, affecting how the body uses glucose and fats through mitochondrial function.
