Testosterone Prevents Cutaneous Ischemia and Necrosis in Males Through Complementary Estrogenic and Androgenic Actions

    March 2017 in “ Arteriosclerosis, thrombosis, and vascular biology ”
    Chantal Chenu, Marine Adlanmérini, Frédéric Boudou … Françoise Lenfant
    Studysummary This study in male mice found that testosterone provides strong protection against skin necrosis after ischemia, working through its estrogenic and androgenic derivatives to enhance skin survival and revascularization, with 17β-estradiol being notably more effective than dihydrotestosterone.
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    Research cited in this study 4

    1. 17β-Estradiol Inhibits Wound Healing in Male Mice via Estrogen Receptor-α American Journal Of Pathology · 2010
    2. Gender Differences in Skin: A Review of the Literature Gender Medicine · 2007
    3. Sexual Hormones in Human Skin Hormone and metabolic research · 2007
    4. Androgen Receptor-Mediated Inhibition of Cutaneous Wound Healing ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2002