Antiandrogenic Therapy With Finasteride Attenuates Cardiac Hypertrophy and Left Ventricular Dysfunction

    January 2015 in “ Circulation ”
    Caroline Zwadlo, Elisa Schmidtmann, Malgorzata Szaroszyk … Joerg Heineke
    Studysummary This study found that finasteride treatment improved cardiac function and reduced heart failure progression in mice, suggesting it could be a potential therapy for pathological cardiac hypertrophy and dysfunction.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on ahajournals.org →
    Discuss this study in the Community →

    Research cited in this study 5

    1. The Dark Side of 5α-Reductase Inhibitors' Therapy: Sexual Dysfunction, High Gleason Grade Prostate Cancer, and Depression Korean Journal of Urology · 2014
    2. Tissue-Selective Regulation of Androgen-Responsive Genes Endocrine Research · 2012
    3. SRD5A3 Is Required for Converting Polyprenol to Dolichol and Is Mutated in a Congenital Glycosylation Disorder Cell · 2010
    4. Testosterone, Cytochrome P450, And Cardiac Hypertrophy The FASEB Journal · 2002
    5. The Clinical Development of a 5α-Reductase Inhibitor, Finasteride The Journal of Steroid Biochemistry and Molecular Biology · 1990

    Related research 3

    1. Anti-Androgenic Therapy with Finasteride Improves Cardiac Function, Attenuates Remodeling, and Reverts Pathologic Gene Expression After Myocardial Infarction in Mice Journal of Molecular and Cellular Cardiology · 2018
    2. Antiandrogenic Therapy With Finasteride Attenuates Cardiac Hypertrophy and Left Ventricular Dysfunction Circulation · 2015
    3. Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Serum Gonadotropins in Normal Men The Journal of Clinical Endocrinology and Metabolism · 1992