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Glossary Antiandrogen Therapy

reduces or blocks male hormones to treat certain conditions

Antiandrogen Therapy, also known as androgen deprivation therapy (ADT), is a treatment that reduces the levels or blocks the effects of androgens (male hormones like testosterone) in the body. This therapy is commonly used to treat conditions like prostate cancer and androgenic alopecia (male pattern baldness) by slowing the growth of cancer cells or reducing hair loss, respectively.

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Research

5 / 1000+ results

research Antiandrogenic Therapy With Finasteride Attenuates Cardiac Hypertrophy and Left Ventricular Dysfunction

56 citations , January 2015 in “Circulation”

This study found that finasteride treatment improved cardiac function and reduced heart failure progression in mice, suggesting it could be a potential therapy for pathological cardiac hypertrophy and dysfunction.

Antiandrogenic Therapy with Cyproterone Acetate in Female Patients with Androgenetic Alopecia and Acne Vulgaris

research Antiandrogenic therapy with ciproterone acetate in female patients who suffer from both androgenetic alopecia and acne vulgaris

5 citations , December 2014 in “Medicine and Pharmacy Reports”

This study found that antiandrogenic therapy with Melleva 35 for three months was effective in reducing hair loss and improving acne in women with both Androgenetic Alopecia and Acne Vulgaris.

research Spironolactone is an Effective and Well Tolerated Systemic Antiandrogen Therapy for Hirsute Women*

78 citations , May 1989 in “The Journal of Clinical Endocrinology & Metabolism”

This study found that in hirsute women, daily treatment with 200 mg spironolactone significantly reduced hair growth rates and hair shaft diameters on various body areas over 12 months.

research ANTIANDROGEN THERAPY IN DERMATOLOGY

32 citations , November 1996 in “International Journal of Dermatology”

This review discusses the use of antiandrogen therapy in dermatology, covering treatments for conditions like acne, hirsutism, and androgenic alopecia but reports no new clinical findings.

research Antiandrogen Therapy for Skin and Hair Disease

20 citations , April 2006 in “Dermatologic Clinics”

This review discusses the role of androgen hormones in skin and hair conditions and highlights the potential of antiandrogen therapies in dermatology, reporting no new results.

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Community Join

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community Cold and Japanese researchers. The Japanese began to suspect something. But they understood the mechanism to some extent. ( Cold shock therapy promotes hair growth in association with upregulation of cold-inducible RNA-binding protein and vascular endothelial growth factor).

36 upvotes 1 year ago

Cold shock therapy may promote hair growth, but cold alone is not effective. Combining treatments like minoxidil, finasteride, cold showers, spicy foods, and exercise may enhance results.

community IGFBP‐rP1 is a potential therapeutic target in androgenic alopecia

in Research/Science 13 upvotes 1 year ago

IGFBP‐rP1 shows potential for treating androgenic alopecia by influencing hair cycle transitions. Increasing IGF-1 levels may have similar effects to Minoxidil and 5-AR inhibitors in reducing hair loss.

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens.

2 upvotes 1 year ago

A method for treating androgenic alopecia using minoxidil, antiandrogens, exercise, and cold exposure to promote hair growth. Environmental factors and lifestyle changes, like diet and exercise, can improve treatment effectiveness.

community Does RU58841 potentially cause cancer?

in Research/Science 1 year ago

RU58841 may pose cancer risks due to its antiandrogen properties and lack of long-term safety data. Using it is considered a high-risk experiment with unknown potential for harm.

community (MTF 35) Results of 18 Months of HRT

775 upvotes 8 months ago

A transgender woman experienced significant hair regrowth after 18 months of hormone replacement therapy (HRT) with estrogen and bicalutamide. The discussion notes HRT's effectiveness for hair regrowth but warns against its use for cisgender men due to feminizing effects.

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Learn

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learn Ketoconazole

antifungal with some anti-androgenic benefits, often used as a shampoo

learn Spironolactone

powerful topical and oral anti-androgen used mostly by women

learn Minoxidil

An essential vasodilator with some anti-androgenic effects

learn Azelaic Acid

acid used for antimicrobial, anti-inflammatory and anti-androgenic properties

learn Bicalutamide

a nonsteroidal anti-androgen, most commonly used orally for women

Can bicalutamide stop DHT from shrinking your hair follicles? Bicalutamide blocks androgens at the receptor rather than lowering DHT, and some dermatologists prescribe it off-label for women with pattern hair loss. The published evidence is retrospective case series and one small pilot study, with no randomized trial; it is a prescription drug that requires liver monitoring and is contraindicated in pregnancy.

learn Clascoterone

Can I use clascoterone if I'm undergoing gender-affirming hormone therapy? No published clinical trial has tested clascoterone in people on gender-affirming hormone therapy, so its safety in that group is unknown. The FDA label reports low systemic exposure and no described effect on blood testosterone, but it also records HPA-axis suppression and raised potassium in a small minority of subjects.

learn Pyrilutamide

Is pyrilutamide a safer alternative to oral antiandrogens like finasteride? Pyrilutamide may be a safer topical alternative to oral antiandrogens like finasteride.

learn GT20029

Is GT20029 safe and effective for both men and women with androgenic alopecia? Not yet. GT20029 is an experimental drug: early trials suggest it is well tolerated, but its effectiveness and long-term safety are unproven, especially in women.

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