research Hidradenitis suppurativa: an-androgen-dependent disorder
Hidradenitis suppurativa improves with antiandrogen therapy.
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research Animal models of androgen-dependent disorders of the pilosebaceous apparatus
Testosterone causes hair loss in AGA mice, which are good for testing baldness treatments, and both minoxidil and cyproterone acetate can prevent this hair loss.
research Defects in Androgen Biosynthesis Causing 46,XY Disorders of Sexual Development
This review describes how recent discoveries in genetic defects and alternative pathways in androgen biosynthesis are reshaping our understanding of male sexual differentiation, but it presents no new clinical findings.
research Androgen-Dependent Beard Dermal Papilla Cells Secrete Autocrine Growth Factor(s) in Response to Testosterone Unlike Scalp Cells
In this study, researchers found that while both beard and scalp dermal papilla cells release similar autocrine growth factors, only beard cells increased production and response with testosterone, suggesting these factors enhance androgen-induced hair growth.
research Androgens Affect the Activity of Human Sebocytes in Culture in a Manner Dependent on the Localization of the Sebaceous Glands and Their Effect Is Antagonized by Spironolactone
This study found that testosterone and 5α-dihydrotestosterone affect human sebocytes differently depending on the skin region, with spironolactone inhibiting their proliferation and counteracting androgen effects in facial sebocytes.
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5 / 1000+ resultscommunity Androgenetic alopecia is a skin disease: DHT-mediated skin disorders
Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.
community Hair Loss Ruins Your Mind: 10x rate of BDD. PF S is not real
Hair loss is linked to a higher rate of body dysmorphic disorder (BDD), OCD, and depression. Finasteride and dutasteride are not linked to increased suicidal risk, though some users report mental health side effects.
community Sugar and Hair loss connections
High sugar diets may worsen hair loss by increasing 5α-reductase activity and androgen levels, especially in women with PCOS. A low sugar diet might reduce scalp DHT levels, similar to finasteride, but genetics also significantly influence hair loss.
community My Theory Of Androgenic Alopecia
Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.
community PSA: Most men who stay on Fin will see the sexual side effects go away. Stop the fear mongering
Finasteride can cause sexual side effects in less than 2% of men, but these often disappear over time, even if the treatment continues. Some users report persistent side effects, while others experience no issues or only temporary ones.
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5 / 801 resultslearn Cyproterone
a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor
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learn Osteopontin
signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss
learn Stem Cell Factor
learn Pyrilutamide
highly targeted anti-androgen that might have minimal systemic effects
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