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Polycystic Ovary Syndrome: A Complex Condition with Psychological, Reproductive, and Metabolic Manifestations That Impacts Health Across the Lifespan

research Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan

926 citations , June 2010 in “BMC Medicine”

This review emphasizes the need for comprehensive guidelines to address the cardiometabolic and psychological features of polycystic ovary syndrome, alongside its reproductive aspects, and reports no new results.

Matrix Effect in Quantitative LC/MS/MS Analyses of Biological Fluids: A Method for Determination of Finasteride in Human Plasma at Picogram Per Milliliter Concentrations

research Matrix Effect in Quantitative LC/MS/MS Analyses of Biological Fluids: A Method for Determination of Finasteride in Human Plasma at Picogram Per Milliliter Concentrations

823 citations , February 1998 in “Analytical Chemistry”

Method detects finasteride in plasma at very low concentrations.

research Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche

695 citations , October 2011 in “Cell stem cell”

This review discusses the metabolic and physiological mechanisms that maintain hematopoietic stem cell function, particularly focusing on oxygen and energy homeostasis, but it reports no new experimental results.

research Maternal nutrition at conception modulates DNA methylation of human metastable epialleles

432 citations , April 2014 in “Nature communications”

This study found that the maternal nutritional status during early pregnancy significantly influenced epigenetic changes in offspring, as maternal diet altered DNA methylation at human metastable epialleles.

research Potential role and therapeutic interests of myo-inositol in metabolic diseases

369 citations , June 2013 in “Biochimie”

This review discusses the potential benefits of myo-inositol supplementation for insulin resistance-related disorders and diabetic complications, but reports no new clinical results.

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community met my dermatoligist today and here is how it went

in Treatment 41 upvotes 9 months ago

A dermatologist advised against using minoxidil and finasteride for hair loss, suggesting acceptance instead, but the individual is considering seeking finasteride from a family doctor. The conversation includes suggestions to try online services or pharmacies for obtaining treatments like finasteride, minoxidil, and ketoconazole shampoo.

community Method for creating 0.01% duta topical solution, will this work?

in Microneedling 4 upvotes 10 months ago

The conversation discusses creating a 0.01% topical dutasteride solution mixed with minoxidil for hair loss treatment, with concerns about absorption and effectiveness. Some users suggest that dutasteride needs specific formulation for better absorption, while others recommend oral use for practicality.

community Meta analysis of minoxidil only vs 5AR inhibitors

in Research/Science 58 upvotes 1 year ago

Oral dutasteride is the most effective for hair regrowth, followed by oral finasteride and minoxidil. Topical finasteride combined with minoxidil is recommended for those avoiding systemic DHT reduction.

community Methods Of Staying Safe On Ru58841 - My 2 Cents

in Research/Science 21 upvotes 1 year ago

RU58841 is used topically to prevent hair loss by blocking DHT, with suggestions to drink grapefruit juice, take breaks, avoid microneedling, and use lower concentrations to reduce side effects. Users discuss applying it at night to minimize systemic absorption.

community Metal particles abraded from dermapen (or dermaroller) needles. Is it possible?

1 upvotes 5 years ago

Concerns about metal particles from dermapen or dermaroller needles potentially entering the skin and lymph nodes, similar to tattoo needles. Discussion includes the possibility of using Minoxidil, finasteride, and RU58841 for hair loss treatment.

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learn Metformin

diabetes drug with anti-inflammatory, immunomodulatory, and insulin-sensitizing properties

Does metformin help control DHT levels that trigger androgenic alopecia? Metformin has been shown to lower circulating androgens in women with PCOS, but no published study has measured scalp DHT, 5-alpha reductase activity in the follicle, or hair density in anyone taking it — so its effect on pattern hair loss is untested, and it is not a DHT blocker.
Can metformin improve scalp health in people with insulin resistance or PCOS? There is no controlled trial showing that metformin improves scalp hair. The PCOS studies most often cited measured unwanted body hair, not scalp density, and a published case report describes hair loss during metformin treatment; any use for hair would be off-label and a decision for a prescribing doctor.
Is metformin used topically for hair loss, or only as an oral tablet? Approved metformin products are oral tablets only; there is no approved topical metformin for hair loss. Published human reports of topical use are a handful of uncontrolled, pharmacy-compounded case reports in scarring alopecia, and the most-cited clinical series actually used the oral drug.
All 4 questions on Metformin →