926 citations
,
June 2010 in “BMC Medicine” This review emphasizes the need for comprehensive guidelines to address the cardiometabolic and psychological features of polycystic ovary syndrome, alongside its reproductive aspects, and reports no new results.
823 citations
,
February 1998 in “Analytical Chemistry” Method detects finasteride in plasma at very low concentrations.
695 citations
,
October 2011 in “Cell stem cell” This review discusses the metabolic and physiological mechanisms that maintain hematopoietic stem cell function, particularly focusing on oxygen and energy homeostasis, but it reports no new experimental results.
432 citations
,
April 2014 in “Nature communications” This study found that the maternal nutritional status during early pregnancy significantly influenced epigenetic changes in offspring, as maternal diet altered DNA methylation at human metastable epialleles.
369 citations
,
June 2013 in “Biochimie” This review discusses the potential benefits of myo-inositol supplementation for insulin resistance-related disorders and diabetic complications, but reports no new clinical results.
343 citations
,
December 2008 in “Endocrine Reviews” This review discusses the various evidence-based and potential applications of metformin in treating and preventing symptoms and complications associated with polycystic ovary syndrome but reports no new clinical results.
305 citations
,
July 2016 in “International Journal of Biological Macromolecules” This review describes the roles of polysaccharides in antitumor, antiviral, and anti-inflammatory activities and introduces methods for their isolation and purification, reporting no new research results.
286 citations
,
January 2009 in “Human Reproduction Update” This study reports that NIH PCOS is linked to more severe metabolic issues, including higher obesity and insulin resistance, compared to non-NIH PCOS phenotypes.
217 citations
,
February 2009 in “The FASEB Journal” This study found that hydrogen peroxide accumulation and reduced methionine sulfoxide repair play a significant role in the oxidative damage linked to senile hair graying.
200 citations
,
October 2009 in “European journal of endocrinology” This review discusses the multifaceted actions of metformin in polycystic ovary syndrome and reports no new clinical results; the authors emphasize metformin's potential benefits in both cardiometabolic and reproductive aspects of PCOS.
192 citations
,
September 2003 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” This study suggests that metformin may be more effective than Dianette in treating moderate to severe hirsutism in women with PCOS, while also reducing markers of insulin resistance.
162 citations
,
January 2015 in “Trends in Endocrinology and Metabolism” This review discusses how women with PCOS have an increased risk of insulin resistance and cardiometabolic features regardless of body fat, and calls for targeted prevention and management strategies.
155 citations
,
August 1991 in “Journal of The American Academy of Dermatology” This article reviews methotrexate's pharmacokinetics and toxicity, emphasizing the role of urinary excretion and leucovorin in avoiding most toxic reactions; it provides no new clinical results.
150 citations
,
February 2008 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” This study suggests that antiandrogens may slightly reduce hirsutism severity compared to placebo, but evidence is weak and their relative efficacy remains uncertain.
137 citations
,
April 2001 in “Journal of Clinical Investigation” This study found that alopecia in VDR-null mice persists despite undetectable vitamin D levels, indicating a defect in epithelial-mesenchymal communication due to the absence of ligand-independent receptor function.
132 citations
,
September 2009 in “Experimental Dermatology” This study introduced a new classification system for distinguishing between anagen VI and early catagen stages in human hair follicle organ culture, using it to confirm eflornithine's ability to induce premature catagen.
132 citations
,
January 1987 in “Annals of Internal Medicine” Methimazole may cause skin defects in babies if taken during pregnancy.
131 citations
,
September 2017 in “Molecular and Cellular Endocrinology” This article discusses the role of androgens in metabolic and reproductive health and reports no new experimental results; the focus is on androgen receptor activation by testosterone and 5α-dihydrotestosterone.
121 citations
,
April 2008 in “The Journal of Clinical Endocrinology & Metabolism” Insulin sensitizers may slightly reduce hirsutism but are less effective than other treatments.
116 citations
,
December 2013 in “European journal of endocrinology” This study found that combining liraglutide with metformin led to greater weight loss and waist circumference reduction than either treatment alone in obese women with PCOS resistant to metformin monotherapy.
115 citations
,
December 1996 in “PubMed” This study observed that the intestinal absorption of selenium varies depending on its chemical form, with selenomethionine being absorbed efficiently and selenium as selenodiglutathione or selenodicysteine being absorbed faster than selenite.
112 citations
,
September 2021 in “BMC Biology” This study found that specific gene expressions during different stages of hair follicle development in Merino sheep are linked to wool-related traits, and may also be relevant to human skin, metabolic, and immune traits.
111 citations
,
November 2010 in “Human Reproduction” This study found that young indigenous South Asian women with polycystic ovary syndrome are more likely to be centrally obese and have metabolic syndrome, particularly with increasing age, higher BMI, and acanthosis nigricans.
105 citations
,
March 2006 in “Human reproduction” This study found that metformin treatment improved health-related quality-of-life, emotional well-being, and sexual satisfaction among women with PCOS, correlated with weight loss and menstrual cycle normalization.
100 citations
,
July 2018 in “Journal of The American Academy of Dermatology” This study found that alopecia areata is linked with a higher prevalence of systemic and psychiatric diseases, suggesting that physicians should monitor for these potential comorbidities.
100 citations
,
November 2017 in “EMBO Reports” This review discusses the roles of metabolism, reactive oxygen species, intracellular pH, and cell morphology in influencing cell fate decisions during stem cell differentiation but reports no new experimental results.
99 citations
,
January 2004 in “Journal of Biological Chemistry” This study found that methylprednisolone can block IgG-induced keratinocyte detachment in an animal model of pemphigus vulgaris, potentially by increasing the synthesis and modifying adhesion molecules.
91 citations
,
December 2017 in “Systems Biology in Reproductive Medicine” This meta-analysis found that lower serum SHBG levels are associated with an increased risk of PCOS, and improving SHBG levels through treatment may reduce PCOS complications.
91 citations
,
November 2007 in “European journal of endocrinology” This study found that metformin improved insulin resistance, hyperandrogenemia, anovulation, and acne in PCOS patients, regardless of their level of obesity or initial insulin resistance.
90 citations
,
August 2002 in “European journal of endocrinology” This study found that metformin treatment significantly improved hair growth in women with PCOS and hirsutism compared to a placebo.