Folliculin Encoded by the BHD Gene Interacts with a Binding Protein, FNIP1, and AMPK, and Is Involved in AMPK and mTOR Signaling

October 2006 in “ Proceedings of the National Academy of Sciences ”

Masaya Baba, Seung‐Beom Hong, Nirmala Sharma, Michelle B. Warren, Michael L. Nickerson, Akihiro Iwamatsu, Dominic Esposito, William Gillette, Ralph F. Hopkins, James L. Hartley, Mutsuo Furihata, Shinya Oishi, Zhen Wei, Terrence R. Burke, W. Marston Linehan, Laura S. Schmidt, Berton Zbar

folliculin BHD gene FNIP1 AMPK mTOR signaling Birt–Hogg–Dubé syndrome hair follicle tumors

TLDR Folliculin helps regulate energy and nutrient sensing, impacting Birt–Hogg–Dubé syndrome.

The study investigated the role of folliculin (FLCN), encoded by the BHD gene, in Birt–Hogg–Dubé syndrome, which involves hair follicle tumors, lung cysts, and renal neoplasia. Researchers identified FNIP1 as a protein interacting with FLCN, involved in AMPK and mTOR signaling pathways crucial for energy and nutrient sensing. FNIP1 was phosphorylated by AMPK, affecting FLCN phosphorylation. The study suggested that FLCN and FNIP1 regulate energy and nutrient sensing, impacting the mTOR pathway, significant for tumor suppression and BHD syndrome pathology. The findings highlighted FLCN's potential tumor-suppressor function and its role in mTOR pathway regulation.

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research Folliculin Encoded by the BHD Gene Interacts with a Binding Protein, FNIP1, and AMPK, and Is Involved in AMPK and mTOR Signaling

475 citations , October 2006 in “Proceedings of the National Academy of Sciences”

Folliculin helps regulate energy and nutrient sensing, impacting Birt–Hogg–Dubé syndrome.